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Rationale of Hemoadsorption during Extracorporeal Membrane Oxygenation Support

机译：体外膜氧合载体血液吸附的理由

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Extracorporeal membrane oxygenation (ECMO) and extracorporeal life support are increasingly used for treating various forms of shock, lung failure, protected interventions and life support including resuscitation. Most patients on ECMO are affected by a systemic inflammatory response caused by the underlying disease as well as the ECMO support itself, which contributes to vasoplegia, multi-organ failure, deterioration and death. Unfortunately, effective strategies for control of inflammation and related organ failure and shock on ECMO are lacking. Recently, a new polystyrene-based device for hemoadsorption, which aims to reduce excessive levels of inflammatory molecules such as interleukins, cytokines as well as damage- and pathogen-associated molecular patterns, has become available. Here we summarize the rationale, available data and technical aspects of polystyrene-based hemoadsorption during ECMO support, and give recommendations based on existing experience.
机译：体外膜氧合（ECMO）和体外寿命支持越来越多地用于治疗各种形式的休克，肺部衰竭，受保护的干预和生命支持，包括复苏。 MEMO的大多数患者受到潜在疾病以及ECMO支持本身引起的全身炎症反应的影响，这有助于对血糖失败，恶化和死亡有贡献。 遗憾的是，缺乏对控制炎症和相关器官衰竭和ECMO冲击的有效策略。 近来，一种用于血液吸附的新型聚苯乙烯基装置，其目的是降低过量水平的炎症分子如白细胞介素，细胞因子以及损伤和病原体相关的分子模式。 在这里，我们总结了ECMO支持期间基于聚苯乙烯的血液吸附的理由，可用数据和技术方面，并根据现有经验提出建议。

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