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首页> 外文期刊>Cytokine >Maximal local and minimal systemic cytokine response to colorectal surgery: the influence of perioperative filgrastim.
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Maximal local and minimal systemic cytokine response to colorectal surgery: the influence of perioperative filgrastim.

机译：对结直肠手术的最大局部和最小全身细胞因子反应：围手术期非格司亭的影响。

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摘要

Thirty consecutive patients scheduled for elective colorectal surgery were prospectively randomized to receive either filgrastim [the recombinant human form of granulocyte colony-stimulating factor (r-metHu-G-CSF)] or placebo blindly. The levels of interleukin (IL-)1beta, tumour necrosis factor-alpha (TNF-alpha), IL-6, IL-8, transforming growth factor-beta (TGF-beta), and IL-10 were determined 5 and 24 h postoperatively from peripheral blood, peritoneal fluid, and wound fluid. The concentrations of all the measured cytokines were enormously higher locally at the operative site than in the systemic circulation. The only difference between the two medication groups was the lower concentration of IL-8 in peripheral blood in the filgrastim-treated patients. The present study shows abundant release of pro- and anti-inflammatory cytokines into the wound and the peritoneal cavity after abdominal surgery. The systemic response to surgery seems to be a secondary and minor reflection of local events. Filgrastim did not have any effect on the studied local cytokine levels at the operative site. Copyright 2001 Academic Press.
机译：前瞻性地将连续30例计划进行结直肠癌手术的患者随机分配至接受非格司亭[重组人形式的粒细胞集落刺激因子（r-metHu-G-CSF）]或安慰剂。在5和24小时内测定白介素（IL-）1β，肿瘤坏死因子-α（TNF-α），IL-6，IL-8，转化生长因子-β（TGF-β）和IL-10的水平术后来自外周血，腹膜液和伤口液。在手术部位，所有测得的细胞因子的浓度都比全身循环中的浓度高得多。两组药物之间的唯一区别是非格司亭治疗的患者外周血中IL-8的浓度较低。本研究表明，腹部手术后，促炎和消炎细胞因子大量释放到伤口和腹膜腔中。对手术的全身反应似乎是局部事件的次要和次要反映。 Filgrastim对手术部位研究的局部细胞因子水平没有任何影响。版权所有2001，学术出版社。

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