...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3.
【24h】

Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3.

机译：胎儿神经上皮细胞的星形胶质细胞分化涉及心肌钙蛋白1诱导的STAT3激活。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cardiotrophin-1 (CT-1) belongs to the interleukin (IL-)6 family of cytokines that share membrane glycoprotein 130 (gp130) as a receptor component critical for signal transduction. We here observed that CT-1 was expressed in mouse fetal neuroepithelial cells, and was capable of inducing astrocyte differentiation from these cells in a synergistic manner with bone morphogenetic protein (BMP)-2, whose expression was also found in the fetal brain. CT-1-induced astrocyte differentiation was solely gp130-dependent. CT-1-stimulation led to promoter activation of the gene for an astrocyte marker, glial fibrillary acidic protein (GFAP), which was clearly inhibited by expression of a dominant negative form of a gp130-downstream transcription factor, signal transducer and activator of transcription 3(STAT3), or by introduction of a mutation in a single STAT3-binding site in the promoter, suggesting a critical role of STAT3 in the CT-1-induced GFAP transcription. These results suggest that astrocyte differentiation in the developing brain involves CT-1-signaling which cooperates with BMP2. Copyright 2001 Academic Press.
机译：心肌营养素1（CT-1）属于白细胞介素（IL-）6家族的细胞因子，它们共享膜糖蛋白130（gp130）作为对信号转导至关重要的受体成分。我们在这里观察到CT-1在小鼠胎儿神经上皮细胞中表达，并且能够与骨形态发生蛋白（BMP）-2协同作用诱导星形胶质细胞从这些细胞分化，该表达也在胎儿脑中发现。 CT-1诱导的星形胶质细胞分化完全取决于gp130。 CT-1刺激导致星形胶质细胞标记神经胶质纤维酸性蛋白（GFAP）基因的启动子激活，而该基因明显受到gp130下游转录因子，信号转导子和转录激活子的显性负性表达的抑制。 3（STAT3），或通过在启动子中的单个STAT3结合位点引入突变，提示STAT3在CT-1诱导的GFAP转录中起关键作用。这些结果表明，正在发育的大脑中星形胶质细胞的分化涉及与BMP2协同作用的CT-1信号传导。版权所有2001，学术出版社。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号