Interleukin (IL-)15 has less activity than IL-2 to promote type 2 cytokine predominance in tumour-associated mononuclear cells from lung cancer patients.

Takeuchi E; Yanagawa H; Suzuki Y; Shinkawa K; Bando H; Sone S

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Interleukin (IL-)15 has less activity than IL-2 to promote type 2 cytokine predominance in tumour-associated mononuclear cells from lung cancer patients.

机译：白细胞介素（IL-）15的活性低于IL-2，以促进肺癌患者肿瘤相关的单核细胞中2型细胞因子的优势。

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Deviation of type 1/type 2 cytokine balance to type 2 predominance may contribute to tumour progression. We investigated effect of interleukin (IL-)15 on modulation of type 1/type 2 balance in addition to non-major histo-compatibility complex (MHC)-restricted killer induction in the tumour-growing site. IL-15 induced significant killer activity in mononuclear cells (MNC) in malignant pleural effusion as well as those in peripheral blood. Pleural MNC produced more IFN-gamma (type 1 cytokine) by incubation with IL-15 or IL-2 than blood MNC. Moreover, IL-4 and IL-5 (type 2 cytokines) production by pleural MNC were observed only by incubation with IL-2, but not with IL-15. These observations suggest that IL-15 has a potent activity to restore type 1/type 2 balance in addition to killer induction in tumour-growing site. Copyright 2001 Academic Press.

机译：1型/ 2型细胞因子平衡向2型优势的偏离可能有助于肿瘤进展。除了非主要组织相容性复合物（MHC）限制肿瘤生长部位的杀手诱导作用之外，我们还研究了白介素（IL-）15对1型/ 2型平衡调节的影响。 IL-15在恶性胸腔积液以及外周血中的单核细胞（MNC）中诱导明显的杀伤活性。与血液MNC相比，通过与IL-15或IL-2孵育，胸膜MNC产生更多的IFN-γ（1型细胞因子）。而且，仅通过与IL-2一起温育观察到了胸膜MNC产生的IL-4和IL-5（2型细胞因子），而与IL-15却没有观察到。这些观察结果表明，IL-15除了在肿瘤生长部位诱导杀手外，还具有恢复1型/ 2型平衡的有效活性。版权所有2001，学术出版社。

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《Cytokine》 |2001年第2期|共5页
作者
Takeuchi E; Yanagawa H; Suzuki Y; Shinkawa K; Bando H; Sone S;
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正文语种 eng
中图分类细胞生物学;
关键词
Interleukin-15; Interleukin-2; Leukocytes; Mononuclear; Lung Neoplasms; Interleukin-4; 白细胞介素15; 白细胞介素2; 白细胞; 单核; 肺肿瘤;

机译：Interleukin-15;Interleukin-2;Leukocytes;Mononuclear;Lung Neoplasms;Interleukin-4;白细胞介素15;白细胞介素2;白细胞;单核;肺肿瘤;

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1. Interleukin (IL-)15 has less activity than IL-2 to promote type 2 cytokine predominance in tumour-associated mononuclear cells from lung cancer patients. [J] . Takeuchi E, Yanagawa H, Suzuki Y, Cytokine . 2001,第2期

机译：白细胞介素（IL-）15的活性低于IL-2，以促进肺癌患者肿瘤相关的单核细胞中2型细胞因子的优势。
2. Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon [J] . Lang Yoo, A-Rum Yoon, Chae-Ok Yun, Cell death & disease. . 2018,第2期

机译：共价ISG15与CHIP的结合可促进其泛素E3连接酶活性并抑制响应I型干扰素的肺癌细胞的生长
3. Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon [J] . Lang Yoo, A-Rum Yoon, Chae-Ok Yun, Cell death & disease. . 2018,第2期

机译：共价ISG15与CHIP的结合可促进其泛素E3连接酶活性并抑制响应I型干扰素的肺癌细胞的生长
4. The clinical efficacy of transfusion of cytokine-induced killer cells combined with chemotherapy and XiaoJi decoction in patients with stage IIIB/IV non-small cell lung cancer [C] . Liuning Li, Jiaying Liu, Xiaoshu Chai, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：细胞因子诱导的杀伤细胞输注结合化学疗法和消积汤治疗IIIB / IV期非小细胞肺癌的临床疗效
5. Regulatory role of cytokines in the development of tumoricidal function in mononuclear phagocytes from different anatomical sites of cancer patients. [D] . Ahn, Mi Chung. 1995

机译：在癌症患者不同解剖部位的单核吞噬细胞中，细胞因子在肿瘤功能发展中的调节作用。
6. Comparative analysis of interleukin 15 and interleukin 2 for induction of killer activity and of type 2 cytokine production by mononuclear cells from lung cancer patients. [O] . E. Takeuchi, H. Yanagawa, Y. Suzuki, 1998

机译：白细胞介素15和白细胞介素2诱导肺癌患者单核细胞杀伤活性和2型细胞因子产生的比较分析。
7. Comparative analysis of interleukin 15 and interleukin 2 for induction of killer activity and of type 2 cytokine production by mononuclear cells from lung cancer patients. [O] . Takeuchi, E., Yanagawa, H., Suzuki, Y., 1998

机译：白细胞介素15和白细胞介素2诱导肺癌患者单核细胞杀伤活性和2型细胞因子产生的比较分析。

Interleukin (IL-)15 has less activity than IL-2 to promote type 2 cytokine predominance in tumour-associated mononuclear cells from lung cancer patients.

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