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首页> 外文期刊>Cytokine >Flt3 ligand pretreatment promotes protective immunity to Listeria monocytogenes.
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Flt3 ligand pretreatment promotes protective immunity to Listeria monocytogenes.

机译：Flt3配体预处理可增强针对单核细胞增生李斯特菌的保护性免疫。

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摘要

Flt3 ligand (Flt3L) plays a critical role in the proliferation, differentiation and survival of haematopoietic progenitor cells. Its potential use in a clinical setting has been suggested. Here, we report that mice administered Flt3L displayed a nine-fold increase in size of their hepatic non-parenchymal cell population and an approximate 365-fold increase in number of mature dendritic cells within their livers. Such mice exhibited an elevated resistance to secondary infections with Listeria monocytogenes, an intracellular bacterial pathogen. More than 2.0 log(10)fewer listeriae were recovered in the livers of Flt3L-treated, than untreated, mice on day 2 following secondary challenge. Importantly, Flt3L-pretreated mice immunized with an avirulent (listeriolysin O-negative) strain of Listeria harbored significantly fewer ( approximately 1.5 log(10)) organisms in their spleens and livers than did control mice immunized with listeriolysin O-negative listeriae and challenged with a lethal dose of bacteria. The latter finding supports a potential role for Flt3L in strategies to develop vaccines to intracellular pathogens. Copyright 2001 Academic Press.
机译：Flt3配体（Flt3L）在造血祖细胞的增殖，分化和存活中起关键作用。已经提出了其在临床环境中的潜在用途。在这里，我们报告说，施用Flt3L的小鼠肝脏非实质细胞群的大小增加了9倍，肝脏内成熟树突状细胞的数量增加了365倍。此类小鼠对单核细胞增生李斯特菌（一种细胞内细菌病原体）的继发感染表现出较高的抵抗力。在二次攻击后的第2天，经Flt3L处理的小鼠（未处理的小鼠）的肝脏中回收了2.0个log（10）更少的李斯特菌。重要的是，用无毒的（李斯特菌溶血素O阴性）李斯特菌菌株免疫的Flt3L预处理小鼠在脾脏和肝脏中所携带的生物体数量明显少于用李斯特菌溶血素O阴性利斯特氏菌免疫的对照小鼠（约1.5 log（10））种生物。致死剂量的细菌。后一个发现支持Flt3L在开发针对细胞内病原体的疫苗的策略中的潜在作用。版权所有2001，学术出版社。

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