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首页> 外文期刊>Brain structure & function >Role of the insula in top-down processing: an intracranial EEG study using a visual oddball detection paradigm
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Role of the insula in top-down processing: an intracranial EEG study using a visual oddball detection paradigm

机译：insula在自上而下处理中的作用：使用视觉奇怪鼠标探地域的颅内EEG研究

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Functional neuroimaging studies suggest that the insular cortexand more especially the anterior insula (aI)is involved in attentional processes and plays a crucial role in the salience network. However, its specific role in attentional processing remains unclear, which is partly attributable to the low temporal resolution of non-invasive neuroimaging techniques. This study aims to examine the spatio-temporal dynamics of visual target processing using intracranial EEG recorded directly from the insula. Eight epileptic patients (four women, age 18-44years) completed a three-stimulus visual oddball task during the extraoperative invasive intracranial EEG (iEEG) monitoring of their drug-resistant seizures. Depth electrodes were implanted in ten insular lobes (5 left and 5 right) and provided a total of 59 recording contacts in the insula. Event-related potentials (ERPs) and high-gamma-band responses (GBRs) were processed offline. Permutation analyses were performed to compare ERP signals across conditions during the P300 (225-400) interval, and modulations of GBRs (70-150Hz) were computed for separate 100ms time windows (from 0 to 1000ms post-stimulus) and compared across conditions using non-parametric Wilcoxon test. Target stimuli were associated with a P300 (250-338ms) component for 39% of contacts implanted in the aI, most probably reflecting voluntary attentional processing. Amplitude was significantly greater for target than for standard stimuli for all of these contacts, and was greater than for novel stimuli for 72%. In the posterior insula (pI), 16% of contacts showed preferential responses to target stimulus in the P300 interval. Increased GBRs in response to targets were observed in 53% of aI contacts (from approximate to 200 to 300ms) and in 43% of pI contacts (from approximate to 400 to 500ms). This study is the first to characterize the spatio-temporal dynamics of visual target processing in the insula using iEEG. Results suggest that visual targets elicit a P300 in the aI which corresponds in latency to the P3b component, suggesting that this region is involved in top-down processing of task-relevant information. GBRs to visual targets occur earlier in the aI than in the pI, further characterizing their respective roles in voluntary attentional processing.
机译：功能性神经影像研究表明，蒙特塞尔群岛更尤其是前肠道（AI）涉及注意力过程，并在显着网络中发挥至关重要的作用。然而，其在注意力处理中的特定作用仍然不清楚，这部分归因于非侵入性神经影像技术的低时间分辨率。本研究旨在使用直接从insula记录的颅内脑电图来检查视觉目标处理的时空动态。八名癫痫患者（四名妇女，18-44年）在抗毒性癫痫发作的异种侵袭性颅内脑电图（IEEG）监测期间完成了三刺激的视觉奇怪性任务。深度电极植入十个凸起的凸起（左侧和5右），并在insula中提供了总共59个记录触点。离线处理事件相关的电位（ERP）和高伽马带响应（GBRS）。进行置换分析以在P300（225-400）间隔期间将ERP信号进行比较，并且计算GBRS（70-150Hz）的调制，用于单独的100ms时间窗口（从0到1000ms后刺激后），并使用条件比较非参数核苷酸测试。目标刺激与P300（250-338Ms）组分相关，39％的植入AI植入，最可能反映自愿预造成加工。对于所有这些触点的标准刺激，靶幅度显着更大，并且大于新型刺激72％。在后肠道（PI）中，16％的触点显示了P300间隔对目标刺激的优先响应。在53％的AI触点（近似为200至300ms）中观察到响应靶标的GBR增加，并以43％的PI触点（从近似为400至500ms）。本研究是第一个特征在于使用IEEG在Insula中的视觉目标处理的时空动态。结果表明，视觉目标在对应于P3B组件的延迟中的AI中引出P300，这表明该区域涉及任务相关信息的自上而下处理。 GBRS到视觉目标在AI中发生比PI更早，进一步表征了他们在自愿注意力处理中各自的作用。

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