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首页> 外文期刊>Brain injury: BI >Epilepsy and brain injury: A case report of a dramatic neuropsychiatric vicious circle
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Epilepsy and brain injury: A case report of a dramatic neuropsychiatric vicious circle

机译：癫痫和脑损伤：戏剧性神经精神真菌循环案件报告

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摘要

Primary objective: Early treatment of epilepsy is warranted to avoid possible severe consequences. This study aimed to assess the value of treatment in a patient who developed epilepsy after major brain surgery. Design: Case description. A 51 years-old man had a history of putative petit mal seizures since adolescence and left frontotemporal lobectomy after a major traffic accident at age 17. He subsequently developed quickly generalizing partial complex seizures, associated with severe behavioural alterations and personality changes; the condition was left untreated. A further seizure-related loss of consciousness led to another traffic accident at age 47. Methods and procedures: The patient was administered 200mg/day topiramate, 600mg/day quetiapine, 1000mg/day valproate, 1200mg/day gabapentin and 800mg/day carbamazepine. Main outcomes and results: The instituted anti-epileptic treatment reduced seizure frequency and severity, but did not affect psychiatric symptomatology, which even worsened. An association between anti-epileptic drugs with mood stabilizing properties and an atypical anti-psychotic dramatically improved psychiatric symptoms, but did not prevent the patient from needing long-term healthcare. Conclusions: Long-term untreated epilepsy may expose to accident proneness and further psychiatric deterioration. Early diagnosis and treatment of epilepsy may help in avoiding a potentially lethal vicious circle.
机译：初级目标：有必要早期治疗癫痫，以避免可能的严重后果。本研究旨在评估主要脑部手术后开发癫痫的患者的治疗价值。设计：案例描述。 51岁的男子在17岁的主要交通事故后，自青春期和左前兆肺切除术，左右颞叶片癫痫发作型Petit Mal癫痫发作历史。他随后发展迅速泛化部分复杂的癫痫发作，与严重的行为改变和人格变化相关;病情未经处理。进一步的癫痫发作相关的意识丧失导致了47岁的另一个交通事故。方法和程序：患者被施用200mg /天托吡酯，600mg /天喹啉，1000mg /天丙酸，1200mg /天加巴巴蛋白和800mg /天的卡巴马嗪。主要结果和结果：所研究的抗癫痫治疗减少癫痫发作频率和严重程度，但不影响精神病症状，甚至恶化。抗癫痫药物与情绪稳定性质和非典型抗精神病患者之间的关联显着改善了精神症状，但没有阻止患者需要长期的医疗保健。结论：长期未经处理的癫痫可能暴露于事故倾向和进一步的精神劣化。癫痫的早期诊断和治疗可能有助于避免潜在的致命恶性循环。

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  • 来源
    《Brain injury: BI》 |2013年第8期|共4页
  • 作者

    RapinesiC.; DelCasaleA.; SerataD.; KotzalidisG.D.; ScatenaP.; MuziA.; LazanioS.; SavojaV.; CarbonettiP.; FensoreC.; FerracutiS.; AngelettiG.; TatarelliR.; GirardiP.;

  • 作者单位

    Department of Neuropsychiatry Suore Hospitaliere of the Sacred Heart of Jesus Villa Rosa Viterbo;

    NESMOS Department (Neurosciences Mental Health and Sensory Organs) Sapienza University Saint;

    Department of Neuropsychiatry Suore Hospitaliere of the Sacred Heart of Jesus Villa Rosa Viterbo;

    NESMOS Department (Neurosciences Mental Health and Sensory Organs) Sapienza University Saint;

    Department of Neuropsychiatry Suore Hospitaliere of the Sacred Heart of Jesus Villa Rosa Viterbo;

    Department of Neuropsychiatry Suore Hospitaliere of the Sacred Heart of Jesus Villa Rosa Viterbo;

    NESMOS Department (Neurosciences Mental Health and Sensory Organs) Sapienza University Saint;

    NESMOS Department (Neurosciences Mental Health and Sensory Organs) Sapienza University Saint;

    Department of Neuropsychiatry Suore Hospitaliere of the Sacred Heart of Jesus Villa Rosa Viterbo;

    Department of Neuropsychiatry Suore Hospitaliere of the Sacred Heart of Jesus Villa Rosa Viterbo;

    NESMOS Department (Neurosciences Mental Health and Sensory Organs) Sapienza University Saint;

    NESMOS Department (Neurosciences Mental Health and Sensory Organs) Sapienza University Saint;

    NESMOS Department (Neurosciences Mental Health and Sensory Organs) Sapienza University Saint;

    Department of Neuropsychiatry Suore Hospitaliere of the Sacred Heart of Jesus Villa Rosa Viterbo;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 头部及神经外科学;
  • 关键词

    Aggression; Anti-epileptic drugs; Brain surgery; Epilepsy; Frontotemporal lobectomy; Traumatic brain injury;

    机译：侵略;抗癫痫药物;脑外脑外;癫痫;终身肺叶切除术;创伤性脑损伤;

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