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首页> 外文期刊>Cytokine >Presence of IFN-gamma and IL-4 in human periapical granulation tissues and regeneration tissues.
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Presence of IFN-gamma and IL-4 in human periapical granulation tissues and regeneration tissues.

机译：人根尖周肉芽组织和再生组织中存在IFN-γ和IL-4。

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摘要

To study mediators associated with the progression of disease and the process of bone regeneration in human apical periodontitis, we examined samples of periapical granulation tissues and regeneration tissues obtained from five patients by use of immunohistochemical methods. Periapical granulation tissues were found to contain a large number of CD4-positive T cells and CD68-positive monocytes/macrophages (CD4: 35.2%, CD68: 32.7%). The CD4-positive T cells and CD68-positive monocytes/macrophages were predominantly present in regeneration tissues (CD4: 62.1%, CD68: 16.0%). In these the percentages of CD4-positive T cells were higher as compared with periapical granulation tissues (from 35.2% to 62.1%). In periapical granulation tissues, CD4-positive T cells stained positively for interferon-gamma (IFN-gamma) and negatively for interleukin-4 (IL-4). In regeneration tissues, IL-4-producing cells could be detected. However, IFN-gamma-producing cells could not be detected. These results suggest that IFN-gamma and IL-4 may modulate the pathogenesis of infectious disease and the process of bone regeneration in local inflammation sites such as human apical periodontitis. Copyright 2001 Academic Press.
机译：为了研究与人类根尖周炎的疾病进展和骨再生过程有关的介质，我们使用免疫组织化学方法检查了五名患者的根尖肉芽组织和再生组织样本。发现根尖肉芽组织包含大量CD4阳性T细胞和CD68阳性单核细胞/巨噬细胞（CD4：35.2％，CD68：32.7％）。 CD4阳性T细胞和CD68阳性单核细胞/巨噬细胞主要存在于再生组织中（CD4：62.1％，CD68：16.0％）。在这些中，CD4阳性T细胞的百分比与根尖肉芽组织相比更高（从35.2％到62.1％）。在根尖肉芽组织中，CD4阳性T细胞的干扰素-γ（IFN-γ）染色呈阳性，而白介素4（IL-4）呈阴性。在再生组织中，可以检测到产生IL-4的细胞。但是，无法检测到产生IFN-γ的细胞。这些结果表明，IFN-γ和IL-4可调节感染性疾病的发病机制以及局部炎症部位（例如人根尖周炎）中骨再生的过程。版权所有2001，学术出版社。

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