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首页> 外文期刊>Cytokine >TH1/TH2 cytokine secretion of first degree relatives of T1DM patients.
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TH1/TH2 cytokine secretion of first degree relatives of T1DM patients.

机译：T1DM患者一级亲属的TH1 / TH2细胞因子分泌。

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摘要

Th1/Th2 cytokine imbalance has been demonstrated in Type 1 diabetes (T1DM) patients. We characterized the peak levels, secretory pattern and total cytokine production of the Th1 cytokines (IL-2 and IFNgamma) and Th2 cytokines (IL-4 and IL-10), by stimulated peripheral blood mononuclear cells of twenty six first-degree relatives of T1DM patients, and eleven matched controls. At enrollment, first degree relatives demonstrated a significant increase in peak and overall secretion of IL-2; P<0.01 and P<0.005 respectively and IL-4 cytokine; P<0.05 and P<0.01 respectively, as compared to normal controls. Their mean IFNgamma secretion increased significantly, P<0.05, after one year while their higher IL-2 and IL-4 secretion remained unchanged. Ab-negative and Ab-positive relatives demonstrated a similar cytokine secretion pattern. Four relatives all Ab positive, developed diabetes: Peak IL-4 levels were low in three and markedly decreased within one year in one of these relatives, while peak IL-2 and IFNgamma levels were elevated in all of them. These data demonstrate that secretion of both Th1 and Th2 cytokines is increased in first-degree relatives of T1DM patients independently of their diabetes-associated autoantibodies. The presence of low IL-4 and elevated IL-2 and IFNgamma levels in autoAb positive relatives is associated with progression to overt disease.
机译：在1型糖尿病（T1DM）患者中已证明Th1 / Th2细胞因子失衡。我们通过刺激二十六个一级亲戚的外周血单核细胞来表征Th1细胞因子（IL-2和IFNgamma）和Th2细胞因子（IL-4和IL-10）的峰值水平，分泌模式和总细胞因子产生。 T1DM患者和十一个匹配的对照。入学时，一级亲属显示出IL-2的峰值和总体分泌显着增加。 IL-4细胞因子分别为P <0.01和P <0.005;与正常对照相比，分别P ＜0.05和P ＜0.01。一年后，其平均IFNγ分泌显着增加，P <0.05，而其较高的IL-2和IL-4分泌保持不变。抗体阴性和抗体阳性的亲戚表现出相似的细胞因子分泌模式。四名亲属均患有Ab阳性，发展中的糖尿病：这些亲戚之一的IL-4峰值水平较低，并且在一年内显着下降，而所有这些亲戚中的IL-2和IFNγ峰值水平均升高。这些数据表明，与糖尿病相关的自身抗体无关，T1DM患者的一级亲属中Th1和Th2细胞因子的分泌均增加。 autoAb阳性亲戚中低IL-4以及升高的IL-2和IFNgamma水平与疾病发展有关。

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