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首页> 外文期刊>Cytokine >Glutathione S-transferase T1 polymorphism is associated with breast cancer susceptibility.
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Glutathione S-transferase T1 polymorphism is associated with breast cancer susceptibility.

机译：谷胱甘肽S-转移酶T1多态性与乳腺癌易感性有关。

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The association between presentull polymorphism of glutathione S-transferase T1 (GSTT1) and breast cancer risk are still inconclusive. We performed a meta-analysis to derive a more precise estimation of the relationship. A total of 48 studies including 17,254 cases and 21,163 controls were involved in this meta-analysis. When all studies were pooled into the meta-analysis, significantly elevated breast cancer risk was associated with null genotype (OR=1.138, 95% CI=1.051-1.232). When stratified by ethnicity, significantly increased risks were found for Caucasians (OR=1.185, 95% CI=1.075-1.306), but no statistically significantly increased risks were found in Asians (OR=1.017, 95% CI=0.846-1.223) and Africans (OR=1.160, 95% CI=0.815-1.650). In the subgroup analysis by controls source, statistically significantly elevated risks were both found in population-based studies (OR=1.123, 95% CI=1.014-1.243) and hospital-based studies (OR=1.181, 95% CI=1.056-1.321). When stratified by menopausal status, no statistically significantly increased risks were found in premenopausal women (OR=1.115, 95% CI=0.925-1.345) and postmenopausal women (OR=1.077, 95% CI=0.992-1.169). In summary, this meta-analysis suggests that the GSTT1 null genotype is a risk allele for breast cancer development. However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding.
机译：谷胱甘肽S-转移酶T1（GSTT1）的当前/无效多态性与乳腺癌风险之间的关系尚无定论。我们进行了荟萃分析，以得出更精确的关系估计。这项荟萃分析共涉及48项研究，包括17,254例和21,163例对照。当所有研究汇总到荟萃分析中时，显着升高的乳腺癌风险与无效基因型相关（OR = 1.138，95％CI = 1.051-1.232）。当按种族进行分层时，发现高加索人的风险显着增加（OR = 1.185，95％CI = 1.075-1.306），而在亚洲人中未发现统计学上显着增加的风险（OR = 1.017，95％CI = 0.846-1.223）和非洲人（OR = 1.160，95％CI = 0.815-1.650）。在对照来源进行的亚组分析中，基于人群的研究（OR = 1.123，95％CI = 1.014-1.243）和基于医院的研究（OR = 1.181，95％CI = 1.056-1.321）均发现统计学上显着升高的风险）。当按绝经状态分层时，绝经前妇女（OR = 1.115，95％CI = 0.925-1.345）和绝经后妇女（OR = 1.077，95％CI = 0.992-1.169）未发现统计学上显着增加的风险。总而言之，这项荟萃分析表明，GSTT1无效基因型是乳腺癌发展的风险等位基因。但是，有必要对同质性乳腺癌患者和匹配良好的对照进行大样本和基于人群的代表性研究，以证实这一发现。

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