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首页> 外文期刊>Cytokine >High plasma fractalkine (CX3CL1) levels are associated with severe liver disease in HIV/HCV co-infected patients with HCV genotype 1.
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High plasma fractalkine (CX3CL1) levels are associated with severe liver disease in HIV/HCV co-infected patients with HCV genotype 1.

机译：血浆fractalkine（CX3CL1）水平高与HIV / HCV共感染HCV基因型1的患者患有严重的肝脏疾病有关。

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BACKGROUND: Inappropriate persistence of chemokines expression in hepatitis C virus (HCV) infection can drive tissue damage, intrahepatic inflammation, and liver cell injury. The aim of study was to study the association of plasma fractalkine (CX3CL1) levels with fibrosis stage and necroinflammatory activity grade of liver biopsies in human immunodeficiency virus (HIV)/HCV co-infected patients with HCV genotype 1. METHODS: We carried out a cross-sectional study on 125 patients. Grading and staging of liver biopsies were carried out by METAVIR score. Plasma CX3CL1 was measured using an immunoassay kit. RESULTS: Patients with advanced fibrosis had higher CX3CL1 levels than those with mild or no fibrosis (p=0.010); and patients with severe activity grade had higher CX3CL1 levels than those with low activity grade (p=0.040). Plasma CX3CL1 levels were significantly associated with increased odds of significant fibrosis (odds ratio (OR): 3.47 (95% of confidence interval (95%CI): 1.04; 11.58)), advanced fibrosis (OR: 6.78 (95%CI: 1.70; 26.93)), and moderate necroinflammatory activity grade (OR: 4.09 (95%CI: 1.21; 13.87)). When we analyzed fibrosis stages and activity grades of METAVIR score together, we found a positive significant association of CX3CL1 levels with moderate activity grade/significant fibrosis (OR: 5.49 (95%CI: 1.46; 20.58)) and moderate activity grade/advanced fibrosis (OR: 8.99 (95%CI: 2.06; 39.23)). CONCLUSION: Plasma CX3CL1 levels were independently associated with several characteristics of severe liver disease in HIV/HCV coinfected patients with HCV-genotype 1, suggesting a role of CX3CL1 in the pathogenesis of HCV infection.
机译：背景：丙型肝炎病毒（HCV）感染中趋化因子表达的不适当持久性可导致组织损伤，肝内炎症和肝细胞损伤。研究的目的是研究人免疫缺陷病毒（HIV）/ HCV共感染HCV基因型1的患者血浆中的fractalkine（CX3CL1）水平与肝活检的纤维化阶段和坏死炎症活性等级的关系。方法：对125名患者进行横断面研究。肝活检的分级和分期通过METAVIR评分进行。使用免疫测定试剂盒测量血浆CX3CL1。结果：晚期纤维化患者的CX3CL1水平高于轻度或无纤维化患者（p = 0.010）;活动度高的患者的CX3CL1水平高于活动度低的患者（p = 0.040）。血浆CX3CL1水平与明显纤维化的几率显着相关（几率（OR）：3.47（95％的置信区间（95％CI）：1.04; 11.58）），晚期纤维化（OR：6.78（95％CI：1.70） ; 26.93）），以及中等程度的炎症反应活性等级（OR：4.09（95％CI：1.21; 13.87））。当我们同时分析纤维化阶段和METAVIR评分的活动等级时，我们发现CX3CL1水平与中度活动等级/严重纤维化（或：5.49（95％CI：1.46; 20.58））和中度活动等级/高级纤维化呈正相关（OR：8.99（95％CI：2.06; 39.23））。结论：血浆CX3CL1水平与HIV / HCV合并感染的HCV基因型1的患者的严重肝病的几个特征独立相关，表明CX3CL1在HCV感染的发病机理中具有作用。

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