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首页> 外文期刊>Cytokine >Macrophage colony stimulating factor and monocyte chemoattractant protein 2 are elevated in intrinsic asthmatics.
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Macrophage colony stimulating factor and monocyte chemoattractant protein 2 are elevated in intrinsic asthmatics.

机译：内在哮喘患者中巨噬细胞集落刺激因子和单核细胞趋化蛋白2升高。

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BACKGROUND: Intrinsic asthma, etiology unknown, occurs later in life, mostly in females. It is associated with nasal polyps and massive eosinopillic infiltration of the respiratory mucous membrane, aspirin intolerance and steroid dependence. The aim of the study was to determine the cytokine and chemokine profile in sera of intrinsic asthmatics and control subjects. METHODS: Blood was taken from 10 intrinsic asthmatic female and 12 control female subjects. Expression profile of 42 different cytokines and chemokines were measured using a microarray composed of antibodies against the cytokines and chemokines. Complete blood count and C-reactive protein were measured, to assess the state of inflammation in both groups. RESULTS: We have identified Macrophage Colony Stimulating Factor, a proinflammatory cytokine and Monocyte Chemoattractant Protein 2, a CC chemokine as having significantly higher expression levels in intrinsic asthmatic subjects compared to controls (341.71+/-31.28 SEM Signal intensity) versus (247.97+/-28.09 SEM Signal intensity), p=0.036 and (397.07+/-38.19 SEM Signal intensity) versus (311.33+/-28.76 SEM Signal intensity), p=0.036, respectively. There were no significant differences in the other cytokines and chemokines measured nor were there any differences in the inflammatory measurements between the two groups except for eosinophil counts, the hall mark of intrinsic asthma. CONCLUSION: Macrophage Colony Stimulating Factor and Monocyte Chemoattractant Protein are elevated in sera of intrinsic asthmatics compared to normal controls. These cytokines may have a critical role in the inflammatory pathology of intrinsic asthma.
机译：背景：内源性哮喘（病因不明）发生在生命的后期，主要发生在女性中。它与鼻息肉和呼吸道粘膜的大量嗜酸性粒细胞浸润，阿司匹林不耐受和类固醇依赖有关。该研究的目的是确定内在哮喘和对照受试者血清中的细胞因子和趋化因子谱。方法：从10名内在哮喘女性和12名对照女性受试者中抽取血液。使用由针对细胞因子和趋化因子的抗体组成的微阵列，测量了42种不同细胞因子和趋化因子的表达谱。测量全血细胞计数和C反应蛋白，以评估两组的炎症状态。结果：我们确定巨噬细胞集落刺激因子，促炎细胞因子和单核细胞趋化蛋白2（CC趋化因子）在固有哮喘患者中的表达水平明显高于对照组（341.71 +/- 31.28 SEM信号强度），高于（247.97 + / -28.09 SEM信号强度），p = 0.036和（397.07 +/- 38.19 SEM信号强度）与（311.33 +/- 28.76 SEM信号强度），p = 0.036。除嗜酸性粒细胞计数（内在哮喘的标志）外，两组之间其他细胞因子和趋化因子的测定无显着差异，炎性测定也无差异。结论：与正常对照组相比，内在哮喘患者的血清中巨噬细胞集落刺激因子和单核细胞趋化因子蛋白升高。这些细胞因子可能在内源性哮喘的炎症病理中起关键作用。

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