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首页> 外文期刊>Cytokine >Increased interleukin-4 and decreased interferon-gamma levels in serum of children with asthma.
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Increased interleukin-4 and decreased interferon-gamma levels in serum of children with asthma.

机译：哮喘患儿血清中白细胞介素4升高，干扰素-γ水平降低。

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BACKGROUND AND PURPOSE: Immune and inflammatory responses, mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with over expression of T helper (Th)-2 cytokine, particularly interleukin (IL)-4 and IL-5, and decreased expression of Th-1 cytokine, IL-2 and IFN-gamma. We hypothesized that there would be an imbalance in the levels of circulating IL-4 and IFN-gamma in the asthmatic subjects. METHOD: We investigated serum levels of IL-4 and IFN-gamma among eighty children (18 steroid-naive, 30 steroid-treated children with asthma and 32 healthy controls) using commercially available ELISA kits. RESULTS: Serum level of IL-4 was significantly higher in steroid-naive group of asthmatic children compared to the healthy control subjects and was lower in steroid-treated group though the level was statistically not significant. In contrast, serum levels of IFN-gamma were significantly lower in both steroid-naive and steroid-treated groups of asthmatic children compared to healthy control subjects. CONCLUSION: The results of our study suggest that serum level of IL-4 may be elevated in concert with decreased level of IFN-gamma in asthma. Determination of serum levels of IL-4 and IFN-gamma may be a useful tool for understanding the disease processes in asthma.
机译：背景和目的：细胞因子介导的免疫和炎症反应在哮喘的病理生理中起着重要的作用。这些反应与T辅助细胞（Th）-2细胞因子，特别是白介素（IL）-4和IL-5的过度表达，以及Th-1细胞因子，IL-2和IFN-γ的表达降低有关。我们假设哮喘患者的循环IL-4和IFN-γ水平会失衡。方法：我们使用市售ELISA试剂盒调查了80名儿童（18名未接受过类固醇的儿童，30名接受过类固醇治疗的哮喘儿童和32名健康对照组）的血清IL-4和IFN-γ水平。结果：与健康对照组相比，未接受类固醇治疗的哮喘儿童的血清IL-4水平明显高于健康对照组，但经类固醇治疗的患者血清IL-4水平较低，尽管该水平在统计学上不显着。相反，与健康对照组相比，未接受过类固醇治疗的哮喘儿童和接受过类固醇治疗的哮喘儿童血清IFN-γ的水平均显着降低。结论：我们的研究结果表明，哮喘患者血清IL-4水平可能升高而IFN-γ水平降低。测定血清IL-4和IFN-γ水平可能是了解哮喘疾病过程的有用工具。

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