...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Exaggerated circulating Th-1 cytokine response in early rheumatoid arthritis patients with nodules
【24h】

Exaggerated circulating Th-1 cytokine response in early rheumatoid arthritis patients with nodules

机译：早期类风湿关节炎结节患者循环Th-1细胞因子反应过度

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Immunohistochemical studies of the rheumatoid nodule (RN) suggest it is a Th1 granuloma, with focal vasculitis, yet the pathogenesis remains unclear and little is known about circulating cytokines in these patients. Objective: We studied circulating cytokines in DMARD-na?ve RA patients to investigate associations with subcutaneous RN. Methods: 149 DMARD-na?ve adults with early RA (symptom duration ≤2. years) were assessed using the Simplified Disease Activity Index (SDAI), and hand and feet radiographs were scored using the modified Larsen method. Circulating cytokines and growth factors representative of T-helper cell 1(Th1) and Th2 cell, macrophages, and fibroblasts were measured using the Bio-Plex? suspension array system. Results: Of 149 patients, 34 (22.8%) had subcutaneous RN, and these patients had more severe disease with higher mean swollen joint counts (p= 0.02), SDAI (p= 0.04) and modified Larsen scores (p= 0.004). There were no differences in Rheumatoid Factor or anti-cyclic citrullinated peptide antibody positivity between patients with RN and those without RN. Patients with RN showed significantly higher levels of circulating IL-12 (p= 0.02), IL-2 (p= 0.048), and VEGF (p= 0.033) levels, with a trend towards higher levels of IL-7 (p= 0.056), IFN-γ (p= 0.059) and IL-8 (p= 0.074) compared to those without RN. Conclusions: DMARD-na?ve early RA patients with RN had more severe disease than those without RN, and showed an exaggerated circulating Th1 and macrophage cytokine profile.
机译：背景：类风湿结节（RN）的免疫组织化学研究表明，它是Th1肉芽肿，伴有局灶性脉管炎，但发病机制仍不清楚，对这些患者的循环细胞因子了解甚少。目的：我们研究了初治DMARD的RA患者的循环细胞因子，以探讨其与皮下RN的关系。方法：使用简化疾病活动指数（SDAI）评估了149名DMARD初发RA早期成人（症状持续时间≤2年），并使用改进的Larsen方法对手和脚的X线照片进行了评分。使用Bio-Plex®检测代表T辅助细胞1（Th1）和Th2细胞，巨噬细胞和成纤维细胞的循环细胞因子和生长因子。悬挂阵列系统。结果：在149例患者中，有34例（22.8％）患有皮下RN，这些患者病情较重，关节肿胀平均数（p = 0.02），SDAI（p = 0.04）和改良的Larsen评分（p = 0.004）。 RN患者和非RN患者之间的类风湿因子或抗环瓜氨酸肽抗体阳性率无差异。 RN患者的循环IL-12（p = 0.02），IL-2（p = 0.048）和VEGF（p = 0.033）水平显着升高，并且有IL-7（p = 0.056）升高的趋势），IFN-γ（p = 0.059）和IL-8（p = 0.074）。结论：初治RN的DMARD初治RA患者比没有RN的患者病情更严重，并且循环Th1和巨噬细胞细胞因子分布过大。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号