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Cytokine profile, metabolic syndrome and cardiovascular disease risk in women with late-onset gestational diabetes mellitus

机译：迟发性妊娠糖尿病妇女的细胞因子谱，代谢综合征和心血管疾病风险

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Inflammation is an important component of the metabolic syndrome (MetS) which could be the link between the metabolic and the cardiovascular consequences of this condition. Gestational diabetes mellitus (GDM) has been recognized as a significant risk factor for MetS and an inflammation component has been described in this disease. The aim of the study was to evaluate the relationships between cytokine concentrations, components of MetS and cardiovascular risk markers in women with late-onset GDM. Women (n=63) with late-onset GDM and 63 controls were enrolled. Clinical variables, and obstetrics and perinatal outcomes were recorded. Relationships between cytokines (TNF-α, leptin, IL6, adiponectin) and endothelial injury markers (VCAM, ICAM and selectine) were analyzed. Control vs. patient data indicated: pre-gestational body mass index (BMI) 23.46±3.73 vs. 26.97±5.07kg/m 2 (p=0.001); TNF-α 2.2±0.8 vs. 3.1±1.5pg/mL (p=0.002); leptin 18714.78±8859.08 vs. 27365.79±16209.67pg/mL (p=0.001); adiponectin 162.42±34.19 vs. 141.54±41.33ng/mL (p=0.04). Multivariate analyses showed that adiponectin had a protective effect (OR=0.9; p=0.02) and BMI carried a significant risk (OR=8.4; p=0.01) for GDM. No differences were found in endothelial injury markers. In conclusion, the cytokine profile in women with late-onset GDM is characterized by high concentrations of TNF-α and leptin and low adiponectin. This profile is related, in large extent, to an increased pregravid BMI which, potentially, may be linked to the future development of both metabolic and cardiovascular disease.
机译：炎症是代谢综合症（MetS）的重要组成部分，可能是这种状况的代谢与心血管后果之间的联系。妊娠糖尿病（GDM）已被认为是MetS的重要危险因素，并且已在该疾病中描述了炎症成分。这项研究的目的是评估晚期GDM妇女的细胞因子浓度，MetS成分和心血管危险标志之间的关系。纳入了晚期GDM和63例对照的女性（n = 63）。记录临床变量，产科和围产期结局。分析了细胞因子（TNF-α，瘦素，IL6，脂联素）与内皮损伤标记物（VCAM，ICAM和选择素）之间的关系。对照vs.患者数据表明：孕前体重指数（BMI）23.46±3.73 vs. 26.97±5.07kg / m 2（p = 0.001）; TNF-α2.2±0.8对3.1±1.5pg / mL（p = 0.002）;瘦蛋白18714.78±8859.08对27365.79±16209.67pg / mL（p = 0.001）;脂联素162.42±34.19 vs.141.54±41.33ng / mL（p = 0.04）。多变量分析表明脂联素具有保护作用（OR = 0.9; p = 0.02），而BMI对GDM具有显着风险（OR = 8.4; p = 0.01）。在内皮损伤标记物上没有发现差异。总之，晚期GDM妇女的细胞因子谱以高浓度的TNF-α和瘦素和低脂联素为特征。该特征在很大程度上与增加的前体重指数有关，这可能与代谢疾病和心血管疾病的未来发展有关。

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