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首页> 外文期刊>Cytokine >Cellular interferon-γ and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: Action LADA 6
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Cellular interferon-γ and interleukin-13 immune reactivity in type 1, type 2 and latent autoimmune diabetes: Action LADA 6

机译：1型，2型和潜在性自身免疫性糖尿病患者的细胞干扰素γ和白介素13免疫反应：行动LADA 6

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Objective: Type 1 diabetes and latent autoimmune diabetes in adults (LADA) are thought to result from immune-mediated β-cell destruction. It remains unclear why LADA is clinically less severe compared to type 1 diabetes. This study aimed to compare the pro-inflammatory (interferon-γ, IFN-γ) and anti-inflammatory (interleukin-13, IL-13) T-cell responses in humans with LADA and type 1 diabetes. Research design and methods: IFN-γ and IL-13 T-cell responses to a panel of 16 (auto)-antigens were tested using an enzyme linked immune-spot technique and peripheral T-cells from 35 patients with type 1 diabetes, 59 patients with type 2 diabetes, 23 LADA patients, and 42 control subjects. Results: LADA and type 1 diabetes patients did not display any statistically significant differences in the frequency of IFN-γ or IL-13 responses to auto-antigenic stimuli, positive control or mitogen. Overall very low T cell reactivity to autoantigens was detected in all groups. IL-13 responses but not IFN-γ responses to recall antigen tetanus toxoid were higher in healthy control subjects compared to patients with type 1 or type 2 diabetes or LADA (P<0.05). Diabetes, independent of type, was associated with weaker response to recall antigen tetanus toxoid. Conclusions: LADA patients are indistinguishable from type 1 diabetes patients for cellular IFN-γ and IL-13 responses upon mitogen and recall antigen stimulation. These results extend previous findings showing that systemic cytokine/chemokine and humoral responses in type 1 diabetes and LADA are similar.
机译：目的：成人的1型糖尿病和潜在的自身免疫性糖尿病（LADA）被认为是由免疫介导的β细胞破坏引起的。尚不清楚为什么LADA在临床上不如1型糖尿病严重。这项研究旨在比较LADA和1型糖尿病患者的促炎性（干扰素-γ，IFN-γ）和抗炎性（白介素13，IL-13）T细胞反应。研究设计和方法：使用酶联免疫斑点技术和35例1型糖尿病患者59的外周T细胞，测试了对一组16种（自身）抗原的IFN-γ和IL-13 T细胞反应2型糖尿病患者，23名LADA患者和42名对照对象。结果：LADA和1型糖尿病患者对自身抗原刺激，阳性对照或促有丝分裂剂的IFN-γ或IL-13反应频率没有任何统计学上的显着差异。在所有组中都检测到总体上T细胞对自身抗原的反应性非常低。与1型或2型糖尿病或LADA的患者相比，健康对照受试者中针对召回抗原破伤风类毒素的IL-13应答而非IFN-γ应答更高（P <0.05）。糖尿病，与类型无关，与召回抗原破伤风类毒素的反应较弱有关。结论：LADA患者与1型糖尿病患者在有丝分裂原和回忆抗原刺激时的细胞IFN-γ和IL-13反应没有区别。这些结果扩展了先前的发现，表明在1型糖尿病和LADA中全身细胞因子/趋化因子和体液反应相似。

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