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首页> 外文期刊>Cytokine >Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease
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Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease

机译：肺或胸膜疾病患者胸腔积液和血液中YKL-40的水平

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Background: YKL-40 (a chitinase-like protein) is an inflammatory biomarker that is associated with lung injury pathogenesis. We aimed to identify the diagnostic values of YKL-40 in pleural effusions and to evaluate circulating YKL-40 levels during multiple etiological pulmonary/pleural diseases and the role of YKL-40 as a monitoring marker of inflammatory pulmonary disease. Methods: Pleural YKL-40 (n=. 197), YKL-39 (the most homologous chitinase-like protein to human YKL-40), and conventional pleural marker levels were measured in patients with pulmonary/pleural disease. Additionally, serum YKL-40 and YKL-39 levels were analyzed in both patients and controls (n=. 432) and serially monitored in patients with asthma (n=. 27) or pneumonia (n=. 22). Results: Pleural YKL-40 levels were higher than those in the serum and highest in tuberculous pleural effusions (TPEs; 1181. ng/mL), followed by parapneumonic, malignant, and cardiogenic effusions (560. ng/mL). The diagnostic accuracy of pleural YKL-40 (0.78) for discriminating between tuberculous and malignant effusion was comparable to or greater than those of YKL-39, total protein, C-reactive protein and CYFRA 21-1, and lower than those of adenosine deaminase (p< 0.05) and carcinoembriogenic antigen (p=. 0.05). Serum YKL-40 levels were higher in the pneumonia group than in the cancer, asthma, or control groups. Following treatment, serum YKL-40 levels were more greatly reduced in pneumonia patients than in asthma patients. Serum YKL-39 levels did not differ between patients and controls. Conclusions: Pleural YKL-40 levels are elevated in TPEs and have fairly good diagnostic efficacy for detecting TPEs. However, adenosine deaminase is more efficient for detecting TPEs than pleural YKL-40. Serum YKL-40 levels are highest during pneumonia compared to common pulmonary/pleural diseases and are more useful for monitoring pneumonia than asthma.
机译：背景：YKL-40（几丁质酶样蛋白）是一种炎症生物标志物，与肺损伤的发病机制有关。我们旨在确定YKL-40在胸腔积液中的诊断价值，并评估多种病因性肺/胸膜疾病期间循环中YKL-40的水平，以及YKL-40作为炎性肺部疾病监测指标的作用。方法：测量肺/胸膜疾病患者的胸膜YKL-40（n = 197），YKL-39（与人YKL-40最相似的几丁质酶样蛋白）和常规胸膜标记物水平。另外，在患者和对照（n = 432）中分析了血清YKL-40和YKL-39的水平，并在患有哮喘（n = 27）或肺炎（n = 22）的患者中进行了连续监测。结果：胸膜YKL-40水平高于血清中，结核性胸腔积液（TPEs; 1181。ng / mL）中最高，其次是肺炎旁，恶性和心源性积液（560. ng / mL）。胸膜YKL-40（0.78）鉴别结核性和恶性积液的诊断准确性与YKL-39，总蛋白，C反应蛋白和CYFRA 21-1相当或更高，但低于腺苷脱氨酶（p <0.05）和致癌性抗原（p = .0.05）。肺炎组的血清YKL-40水平高于癌症，哮喘或对照组。治疗后，肺炎患者的血清YKL-40水平比哮喘患者降低得多。患者和对照组之间的血清YKL-39水平没有差异。结论：TPEs中胸膜YKL-40水平升高，对TPEs检测具有相当好的诊断功效。但是，腺苷脱氨酶比胸膜YKL-40更有效地检测TPE。与常见的肺/胸膜疾病相比，肺炎期间的血清YKL-40水平最高，比哮喘更适用于监测肺炎。

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