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首页> 外文期刊>Cytokine >Xiangyang, Z.a , Lutian, Y.a b , Lin, Z.a , Liping, X.a , Hui, S.a , Jing, L.a Increased levels of interleukin-33 associated with bone erosion and interstitial lung diseases in patients with rheumatoid arthritis
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Xiangyang, Z.a , Lutian, Y.a b , Lin, Z.a , Liping, X.a , Hui, S.a , Jing, L.a Increased levels of interleukin-33 associated with bone erosion and interstitial lung diseases in patients with rheumatoid arthritis

机译：向阳，Z.a，卢田，Y.a b，林，Z.a，黎平，X.a，回，S.a，荆，L.a类风湿性关节炎患者中与骨侵蚀和间质性肺病相关的白细胞介素33水平升高

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Objective: To analyze the levels of interleukin-33 (IL-33) in the serum of patients with rheumatoid arthritis (RA) and investigated its possible pathophysiological importance. Methods: The concentrations of IL-33 and matrix metalloproteinase (MMP)-3 were measured by enzyme-linked immunosorbent assay (ELISA) in the serum of 121 patients with RA and 47 controls. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), and anticyclic citrullinated peptide (anti-CCP) were measured by standard laboratory techniques. Interstitial lung disease (ILD) was identified on high-resolution computed tomography. Disease activity in RA was scored with the Disease Activity Score 28 based on C-reactive protein levels (DAS28-CRP). The bone erosion of RA patients was evaluated by modified Sharp Score (MSS). Results: Serum levels of IL-33 and MMP-3 were significantly higher in RA patients than in healthy controls. Significant higher levels of IL-33 were found in CCP-positive group and in patients with ILD. There was positive correlation between the levels of IL-33 and RF. Moreover, there was also positive correlation between IL-33 and MMP-3, MSS. Conclusion: These data support the hypothesis that IL-33 may be involved in RA pathogenesis and it may partly contribute to the bone erosion in RA patients.
机译：目的：分析类风湿关节炎（RA）患者血清中白介素33（IL-33）的水平，并探讨其可能的病理生理意义。方法：采用酶联免疫吸附法（ELISA）检测121例RA患者和47例对照者血清中IL-33和基质金属蛋白酶（MMP）-3的浓度。通过标准实验室技术测量红细胞沉降率（ESR），C反应蛋白（CRP），类风湿因子（RF）和抗环瓜氨酸肽（anti-CCP）。间质性肺疾病（ILD）在高分辨率计算机断层扫描上确定。根据C反应蛋白水平（DAS28-CRP），将RA中的疾病活动与疾病活动评分28进行评分。 RA患者的骨侵蚀通过改良的Sharp Score（MSS）进行评估。结果：RA患者的血清IL-33和MMP-3水平显着高于健康对照组。在CCP阳性组和ILD患者中发现了较高的IL-33水平。 IL-33与RF水平呈正相关。此外，IL-33与MMP-3，MSS之间也呈正相关。结论：这些数据支持IL-33可能参与RA发病机理的假设，并且可能部分地导致RA患者的骨侵蚀。

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