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首页> 外文期刊>Cytokine >Genetic variant of the G-CSF receptor gene is associated with lower mobilization potential and slower recovery of granulocytes after transplantation of autologous peripheral blood progenitor cells
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Genetic variant of the G-CSF receptor gene is associated with lower mobilization potential and slower recovery of granulocytes after transplantation of autologous peripheral blood progenitor cells

机译：G-CSF受体基因的遗传变异与自体外周血祖细胞移植后的动员潜力较低和粒细胞的恢复较慢有关

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摘要

Peripheral blood mobilized by cytokines (i.e. granulocyte colony stimulating factor, G-CSF) and chemotherapy has become a major source of hematopoietic stem and progenitor cells for transplantation (PBPCT). In this study the effect of the G-CSF receptor (CSF3R) gene polymorphism was investigated. The presence of the CSF3R variant (T allele, rs3917924) was related to CD34 + mobilization yield and the pace of granulocyte recovery after autologous PBPCT. The mobilization yield was higher in patients lacking the CSF3R variant (OR=4.756, p=0.046) and those with multiple myeloma (OR=10.534, p=0.019). The pace of granulocyte recovery was found to be associated with the CSF3R polymorphism and was significantly slower in patients carrying the CSF3R-T variant than in CC homozygotes (median of 17 vs. 13days, p0.001). This association was confirmed (OR=4.445, p=0.014) by multiple regression analysis considering patient age and sex, the number of transplanted CD34 + cells, diagnosis and CSF3R polymorphism. These results imply that CSF3R gene polymorphism plays a significant role in PBPCT.
机译：通过细胞因子（即粒细胞集落刺激因子，G-CSF）和化学疗法动员的外周血已经成为用于移植的造血干细胞和祖细胞的主要来源（PBPCT）。在这项研究中，研究了G-CSF受体（CSF3R）基因多态性的影响。 CSF3R变异体（T等位基因，rs3917924）的存在与CD34 +动员产量和自体PBPCT后粒细胞恢复的步伐有关。缺乏CSF3R变异的患者（OR = 4.756，p = 0.046）和患有多发性骨髓瘤的患者（OR = 10.534，p = 0.019）的动员率更高。发现粒细胞恢复的速度与CSF3R多态性有关，并且在携带CSF3R-T变异体的患者中比CC纯合子慢得多（中位数为17天与13天，p <0.001）。通过考虑患者年龄和性别，移植的CD34 +细胞数量，诊断和CSF3R多态性的多元回归分析，证实了这种关联（OR = 4.445，p = 0.014）。这些结果暗示CSF3R基因多态性在PBPCT中起重要作用。

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