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首页> 外文期刊>Cytokine >Pilot study of interleukin-27 in pathogenesis of dermatomyositis and polymyositis: Associated with interstitial lung diseases
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Pilot study of interleukin-27 in pathogenesis of dermatomyositis and polymyositis: Associated with interstitial lung diseases

机译：白细胞介素27在皮肌炎和多发性肌炎发病中的初步研究：与间质性肺疾病相关

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Objective: To determine whether interleukin (IL)-27 is involved in dermatomyositis (DM) and polymyositis (PM). Methods: Serum IL-27, IL-18 and interferon-γ (IFN-γ) levels in 37 DM and 15 PM were detected by enzyme-linked immunosorbent assay (ELISA). Results: Serum IL-27, IL-18 and IFN-γ levels were significantly higher in DM and PM patients than in healthy controls. Significant higher levels of IL-27 were found in high creatine kinase (CK) level group and in patients with interstitial lung disease (ILD). Level of IL-27 was correlated with global 100-mm visual analog scales (VASs) score in patients with PM. Conclusion: These data supports the hypothesis that IL-27 maybe involved in DM and PM pathogenesis.
机译：目的：确定白介素（IL）-27是否与皮肌炎（DM）和多发性肌炎（PM）有关。方法：采用酶联免疫吸附法（ELISA）检测37 DM和15 PM中的血清IL-27，IL-18和干扰素-γ（IFN-γ）水平。结果：DM和PM患者的血清IL-27，IL-18和IFN-γ水平显着高于健康对照组。在高肌酸激酶（CK）水平组和间质性肺病（ILD）患者中发现了较高的IL-27水平。 IL-27水平与PM患者的整体100毫米视觉模拟量表（VASs）评分相关。结论：这些数据支持IL-27可能参与DM和PM发病机理的假说。

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