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首页> 外文期刊>Cytokine >Inflammatory cytokines and NT-proCNP in Parkinson's disease patients
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Inflammatory cytokines and NT-proCNP in Parkinson's disease patients

机译：帕金森氏病患者的炎症细胞因子和NT-proCNP

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Introduction: The role of inflammatory factors in Parkinson's disease (PD) has not been consistently proven yet. Despite the presence of some potentially causative factors, the primary and initiating factor has not been determined. Therefore the influence of proinflammatory and antiphlogistic factors on the risk of PD remains unclear. The aim of the study was to evaluate the level of NT-proCNP as well as proinflammatory factors in peripheral blood of patients with PD and to compare the changes of cytokines and NT-proCNP profile of these patients with the profile within the control group. Materials and methods: The study group consisted of 60 patients with the diagnosis of idiopathic PD, in the mean age of 59 ± 15.5. years, and control group of 24 persons, in the mean age of 64 ± 5.8. years, without neurodegenerative and inflammatory disorders. The quantitative determination of cytokines was evaluated with the fluorokineMAP cytokine multiplex kit and the Luminex 100 Platform. ELISA kits were used for the quantitative determination of human NT-proCNP. Results: The levels of NT-proCNP and all measured cytokines were higher in serum of PD patients in comparison to the control group, though the significant differences were only observed in relation to serum level of NT-proCNP (p<0.05) and TNF-α (p<0.001). The mean serum level of NT-proCNP in PD patients correlates with the level of TNF-α (R=0.359, p<0.05) and IL-10 (R=-0.39, p=0.05). There are also other correlations in serum of PD group: between IL-10 and IL-12 (R=0.39, p=0.05), IL-6 and IL-1? (R=0.65, p=0.05). The serum level of IL-6 is also in a positive relation with H&Y stage (R=0.27, p=0.05). Conclusions: The concentration of NT-proCNP and TNF-α is essentially higher in parkinsonian patients than in healthy group. The levels of other anti- and proinflammatory cytokines also tend to be higher in PD patients in comparison to the control group. It confirms the significance of these factors' influence on molecular pathogenesis of PD and makes NT-proCNP a new potential determinant of inflammation in PD patients.
机译：简介：炎症因子在帕金森氏病（PD）中的作用尚未得到一致的证实。尽管存在某些潜在的致病因素，但尚未确定主要因素和引发因素。因此，促炎和消炎因子对PD风险的影响尚不清楚。这项研究的目的是评估PD患者外周血中NT-proCNP的水平以及促炎因子，并将这些患者的细胞因子和NT-proCNP的变化与对照组的变化进行比较。材料和方法：研究组由60例诊断为特发性PD的患者组成，平均年龄为59±15.5。年，对照组为24人，平均年龄为64±5.8。年，没有神经退行性和炎症性疾病。细胞因子的定量测定是通过fluorokineMAP细胞因子多重检测试剂盒和Luminex 100 Platform进行的。 ELISA试剂盒用于人类NT-proCNP的定量测定。结果：与对照组相比，PD患者血清中NT-proCNP水平和所有测得的细胞因子均较高，尽管仅在血清NT-proCNP和TNF-α方面存在显着差异（p <0.05）。 α（p ＜0.001）。 PD患者的平均血清NT-proCNP水平与TNF-α（R = 0.359，p <0.05）和IL-10（R = -0.39，p = 0.05）水平相关。 PD组血清中还存在其他相关性：IL-10和IL-12之间（R = 0.39，p = 0.05），IL-6和IL-1？ （R ＝ 0.65，p ＝ 0.05）。 IL-6的血清水平也与H＆Y阶段呈正相关（R = 0.27，p = 0.05）。结论：帕金森病患者的NT-proCNP和TNF-α浓度明显高于健康组。与对照组相比，PD患者中其他抗炎和促炎细胞因子的水平也往往更高。它证实了这些因素对PD分子发病机理的重要意义，并使NT-proCNP成为PD患者炎症的新潜在决定因素。

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