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首页> 外文期刊>Cytokine >Need for clarification of data in a recent meta-analysis on vascular endothelial growth factor (VEGF) and risk of breast cancer
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Need for clarification of data in a recent meta-analysis on vascular endothelial growth factor (VEGF) and risk of breast cancer

机译:在最近关于血管内皮生长因子(VEGF)和乳腺癌风险的荟萃分析中需要澄清数据

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摘要

Recently, we read with great interest the recent paper by Wang et al. [1 ]. The authors performed a meta-analysis of 10 case-control studies to examine the association between five polymorphisms of vascular endothelial growth factor (VEGF) (i.e., VEGF + 936C/T, -1154A/G, -2578C/A, -634G/C and -460T/C) and risk of breast cancer. Their meta-analysis suggests that the VEGF + 936C/T, -1154A/G, -2578C/A, -634G/C and -460T/C polymorphisms may be not associated with risk of breast cancer development based on the currently available studies, especially among Caucasians. It is an interesting study. Nevertheless, we would like to raise several concerns related to this article.
机译:最近,我们非常感兴趣地阅读了Wang等人的最新论文。 [1]。作者对10个病例对照研究进行了荟萃分析,以研究五种血管内皮生长因子(VEGF)多态性之间的关联(即VEGF + 936C / T,-1154A / G,-2578C / A,-634G / C和-460T / C)和患乳腺癌的风险。他们的荟萃分析表明,根据目前可获得的研究,VEGF + 936C / T,-1154A / G,-2578C / A,-634G / C和-460T / C多态性可能与乳腺癌的发生风险无关,特别是在高加索人中。这是一个有趣的研究。但是,我们想提出与本文相关的一些问题。

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