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Relationship between FOXP3 positive populations and cytokine production in systemic lupus erythematosus

机译：FOXP3阳性人群与系统性红斑狼疮细胞因子产生的关系

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In this work we studied CD4+FOXP3+ populations in systemic lupus erythematosus (SLE) and the relationship with Th cytokine production. We found an increment in CD25-FOXP3+ population in SLE associated with CD4+ downregulation and disease progression. CD25low cells were also upregulated and showed increased percentages of FOXP3+ and CD127-/low cells, supporting the activated status of SLE lymphocytes. Despite the normal levels of CD25highFOXP3+ cells, the negative correlations observed in controls with the frequency of IFNγ, TNFα and IL-10 secreting cells were disrupted in patients, supporting a defective Treg function. Also, CD25high cells showed an altered balance in the production of these cytokines. In addition, CD25highFOXP3+ cells correlated directly with IL-17A and IL-8 but not with TGFβ in SLE. The increased proportion of IL-17+ cells among the CD25high subset and the positive correlation between IL-17 levels and Treg cells suggest a trans-differentiation of Treg into Th17 cells in SLE.
机译：在这项工作中，我们研究了系统性红斑狼疮（SLE）中CD4 + FOXP3 +的种群以及与Th细胞因子产生的关系。我们发现SLE中CD25-FOXP3 +群体的增加与CD4 +的下调和疾病的发展有关。 CD25low细胞也被上调，显示FOXP3 +和CD127- / low细胞的百分比增加，支持SLE淋巴细胞的激活状态。尽管CD25highFOXP3 +细胞水平正常，但患者中与对照组中观察到的与IFNγ，TNFα和IL-10分泌细胞频率的负相关性却被破坏，从而支持了Treg功能的缺陷。同样，CD25high细胞在这些细胞因子的产生中显示出平衡的改变。此外，CD25highFOXP3 +细胞与SLE中的IL-17A和IL-8直接相关，而与TGFβ不相关。 CD25high亚群中IL-17 +细胞比例的增加以及IL-17水平与Treg细胞之间的正相关性表明，Sreg中Treg的转分化为Th17细胞。

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