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首页> 外文期刊>Cytokine >High tumor necrosis factor-α/interleukin-10 ratio is associated with hepatocellular carcinoma in patients with chronic hepatitis C
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High tumor necrosis factor-α/interleukin-10 ratio is associated with hepatocellular carcinoma in patients with chronic hepatitis C

机译：慢性丙型肝炎患者高肿瘤坏死因子-α/白介素-10比值与肝细胞癌相关

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Hepatitis C virus (HCV) is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC) worldwide. The risk for the development of HCC increases with the severity of liver inflammation and fibrosis. The hepatic inflammation caused by HCV involves host regulatory immune response, which is mediated by cytokines with anti-viral role upon the interaction of viral polypeptides with innate and adaptive immunity. Two cytokines; tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) play key roles in the regulation of cellular immune response in HCV infection. The aim of the present study was to determine the levels of IL-10 and TNF-α, as well as the ratio of TNF-α and IL-10 serum levels in patients with HCV and HCC caused by HCV (HCC-HCV). The study included 173 patients with chronic HCV. TNF-α and IL-10 serum levels were measured by ELISA (R&D Systems, Inc.). In the present study, 54 patients presented liver mild fibrosis, 68 had severe fibrosis and 51 patients had HCC. After adjustment in the multivariate regression analysis, the following variables remained significantly associated with HCC-HCV occurrence: diabetes (. p=. 0.012 OR 10.44 CI 1.66-65.60), IL-10 lower levels (. p<. 0.0001 OR 0.83 CI 0.78-0.89) and TNF-α higher levels (. p<. 0.0001 OR 1.19 CI 1.11-1.28). Individuals with HCC presented higher TNF-α/IL-10 ratio than those with fibrosis grade F4, F3 or F0. +. F1. +. F2 (. p=. 0.0003, p<. 0.0001, p<. 0.0001, respectively). Patients with HCC were associated to higher index TNF-α/IL-10 ratio, suggesting that the unbalanced production of these cytokines may represent progression to the liver disease severity in HCV infected patients.
机译：丙型肝炎病毒（HCV）是全球范围内慢性肝病，肝硬化和肝细胞癌（HCC）的主要原因。肝炎和肝纤维化的严重程度增加了发生肝癌的风险。 HCV引起的肝炎症涉及宿主调节性免疫反应，该反应是由具有先天性和适应性免疫力的病毒多肽相互作用时具有抗病毒作用的细胞因子介导的。两种细胞因子;肿瘤坏死因子-α（TNF-α）和白细胞介素10（IL-10）在HCV感染中调节细胞免疫应答中起关键作用。本研究的目的是确定由HCV（HCC-HCV）引起的HCV和HCC患者的IL-10和TNF-α的水平，以及TNF-α和IL-10血清水平的比率。该研究包括173例慢性HCV患者。通过ELISA（R＆D Systems，Inc。）测量TNF-α和IL-10血清水平。在本研究中，有54例肝轻度纤维化患者，68例严重肝纤维化和51例HCC患者。在多元回归分析中进行调整后，以下变量仍与HCC-HCV发生显着相关：糖尿病（。p = .0.012或10.44 CI 1.66-65.60），IL-10降低（。p <。0.0001或0.83 CI 0.78 -0.89）和更高的TNF-α水平（。p <.0.0001或1.19 CI 1.11-1.28）。与肝纤维化等级F4，F3或F0的患者相比，HCC患者的TNF-α/ IL-10比率更高。 +。 F1。 +。 F2（分别为.p ＝ 0.0003，p ＜.0.0001，p ＜.0.0001）。患有HCC的患者与更高的TNF-α/ IL-10指数相关，这表明这些细胞因子的不平衡产生可能代表了HCV感染患者肝病严重程度的发展。

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