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GM-CSF is not essential for optimal fertility or for weight control

机译:GM-CSF对于获得最佳生育力或控制体重并非必不可少

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Independent studies with GM-CSF-/- mice have concluded that GM-CSF is necessary for normal reproductive outcome and for the maintenance of normal weight. In contrast to the literature we report that GM-CSF-/- and wild type (C57Bl/6) mice over a continuous 12. month period had similar litter size and neonatal survival. Likewise, unlike a literature observation, for the two mouse strains both male and female mice had similar weight gain when fed on a normal chow diet and monitored until 30. weeks of age. It is concluded that GM-CSF is not necessary for an optimal fertility outcome or for normal weight maintenance during development.
机译:GM-CSF-/-小鼠的独立研究得出结论,GM-CSF对于正常的生殖结果和维持正常的体重是必需的。与文献相反,我们报道了连续12个月的GM-CSF-/-和野生型(C57Bl / 6)小鼠产仔数和新生儿存活率相似。同样,与文献观察不同的是,对于两种小鼠品系,当以正常食物饮食并监测到30周龄时,雄性和雌性小鼠的体重增加均相似。结论是,GM-CSF对于最佳生育力结果或发育过程中正常体重维持不是必需的。

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