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The age-dependency of genetic and environmental influences on serum cytokine levels: A twin study

机译：遗传和环境影响对血清细胞因子水平的年龄依赖性：一项孪生研究

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摘要

Previous epidemiologic studies have evaluated the use of immunological markers as possible tools for measuring ageing and predicting age-related pathology. The importance of both genetic and environmental influences in regulation of these markers has been emphasized. In order to further evaluate this relationship, the present study aims to investigate the relative influence of genetic and environmental factors on four key cytokines involved in the human immune response (Interleukin (IL)-1β, IL-6, IL-10 and Tumor Necrosis Factor (TNF)-α). In addition, the role of age as a possible moderator on these influences was evaluated. Methods: The study was conducted in 1603 females from the Twins UK registry, with mean age ±SD of 60.4 ± 12.2. years, including 863 monozygotic twins (385. pairs and 93 singletons) and 740 dizygotic twins (321. pairs and 98 singletons). Heritability was estimated using structural equation modeling. The role of age as a moderator was evaluated using gene-age interaction models. Results: Heritabilities were moderate for IL-1β (range: 0.27-0.32) and IL-10 (0.30) and low for IL-6 (range: 0.15-0.16) and TNF-α (range: 0.17-0.23). For IL-1β, heritability declines with age due to an increase in unique environmental factors. For TNF-α, heritability increases with age due to a decrease in unique environmental factors. Conclusion: The current findings illustrate the importance of genetic and environmental influences on four cytokines involved in the human immune response. For two of these there is evidence that heritability changes with age owing to changes in environmental factors unique to the individual.
机译：先前的流行病学研究已经评估了使用免疫学标记物作为测量衰老和预测与年龄相关的病理的可能工具。已经强调了遗传和环境影响在调节这些标志物中的重要性。为了进一步评估这种关系，本研究旨在研究遗传和环境因素对参与人类免疫应答的四种关键细胞因子（白介素（IL）-1β，IL-6，IL-10和肿瘤坏死）的相对影响。因子（TNF）-α）。此外，评估了年龄作为这些影响因素的可能调节者的作用。方法：该研究在Twins UK登记处的1603名女性中进行，平均年龄±SD为60.4±12.2。年，包括863个单卵双胞胎（385对和93个单身）和740个双卵双胞胎（321个对和98个单身）。使用结构方程模型估算遗传力。使用基因-年龄相互作用模型评估了年龄作为调节者的作用。结果：IL-1β（范围：0.27-0.32）和IL-10（0.30）的遗传力中等，IL-6（范围：0.15-0.16）和TNF-α（范围：0.17-0.23）的遗传力低。对于IL-1β，由于独特的环境因素的增加，遗传力随年龄下降。对于TNF-α，由于独特的环境因素的减少，遗传力随年龄增加。结论：目前的发现说明遗传和环境影响对参与人类免疫应答的四种细胞因子的重要性。对于其中的两个，有证据表明，由于个体独特的环境因素的变化，遗传力随年龄而变化。

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