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首页> 外文期刊>Cytokine >High inflammation and mild demyelination in the peripheral nervous system induced by an intraneural injection of RR interleukin-4.
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High inflammation and mild demyelination in the peripheral nervous system induced by an intraneural injection of RR interleukin-4.

机译：神经内注射RR白细胞介素4引起的高炎症和周围神经系统的轻度脱髓鞘。

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摘要

To examine the direct effects of IL-4 on peripheral nervous system (PNS) we injected recombinant rat IL-4 (rrIL-4) into the sciatic nerve of normal adult Lewis rats. Histopathological and immunohistochemical observations revealed that 1 day after injection, a large number of macrophages and MHC class II-positive cells appeared within both the perineurium and endoneurium. Only few CD4(+)and CD8(+)T cells existed in the endoneurium. From day 4 to day 7, we observed a gradual decline of inflammation, but the number of infiltrates in rrIL-4 injected nerves was significantly higher compared with sterile PBS-injected control group. On the contrary, demyelination affected significantly fewer nerve fibres in the rrIL-4-injected nerves compared with control group on day 7. Intraneural injection of rrIL-4 results in high grade inflammation and mild demyelination in the PNS. Copyright 2000 Academic Press.
机译：为了检查IL-4对周围神经系统（PNS）的直接作用，我们将重组大鼠IL-4（rrIL-4）注射到正常成年Lewis大鼠的坐骨神经中。组织病理学和免疫组织化学观察结果表明，注射后1天，会阴部和神经内膜均出现大量巨噬细胞和MHC II类阳性细胞。神经内膜中仅存在少量CD4（+）和CD8（+）T细胞。从第4天到第7天，我们观察到炎症逐渐减轻，但是与注射无菌PBS的对照组相比，注射rrIL-4的神经中的浸润数目明显更高。相反，与第7天的对照组相比，脱髓鞘作用对注射rrIL-4的神经的神经纤维的影响明显少于对照组。神经内注射rrIL-4会导致PNS发生高度炎症和轻度脱髓鞘。版权所有2000学术出版社。

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