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首页> 外文期刊>Cytokine >The diminished postoperative capacity of blood leukocytes to produce IL-6 is associated with high concentrations of IL-6 in the circulation.
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The diminished postoperative capacity of blood leukocytes to produce IL-6 is associated with high concentrations of IL-6 in the circulation.

机译：血液白细胞产生IL-6的术后能力下降与循环中高浓度的IL-6相关。

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摘要

Surgical trauma is followed both by a transient increase of interleukin 6 (IL-6) concentrations in the serum and impaired function of circulating leukocytes. Perioperatively, we investigated the relationship of IL-6 concentrations in the serum with lipopolysaccharide (LPS)-stimulated cytokine production in the whole blood of patients undergoing elective major abdominal operations. In 50 patients, we found a transient increase of IL-6 concentrations in the serum. Six hours after skin incision, in vitro stimulated production of IL-6 and TNFalpha was diminished by 72% (P<0.05). A significant increase in cytokine production was observed three days postoperatively, however this was 63% below the preoperative values. Patients with high concentrations of circulating IL-6 showed a significantly lower stimulated IL-6 production than patients with low serum concentrations of IL-6. We conclude, that two opposing effects are associated with surgery: an activation leading to IL-6-release into the circulation, and a prolonged hyporesponsiveness of circulating leukocytes. These reactions are positively related.
机译：外科手术创伤后，血清中白介素6（IL-6）浓度会暂时升高，循环白细胞功能也会受损。围手术期，我们调查了选择性大腹部手术患者全血中血清IL-6浓度与脂多糖（LPS）刺激的细胞因子产生的关系。在50位患者中，我们发现血清中IL-6浓度瞬时升高。皮肤切口后六小时，体外刺激的IL-6和TNFα的产生减少了72％（P <0.05）。术后三天观察到细胞因子产生显着增加，但是比术前值低63％。血清IL-6浓度高的患者循环IL-6浓度高，其刺激的IL-6产生显着降低。我们得出的结论是，与手术相关的两个相对作用是：激活导致IL-6释放进入循环系统，以及循环白细胞持续时间过低。这些反应是正相关的。

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