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首页> 外文期刊>Cytokine >Interleukin 4 and 13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks.
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Interleukin 4 and 13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks.

机译：白细胞介素4和13参与分枝杆菌（1型）和血吸虫（2型）抗原引起的肺肉芽肿形成：细胞募集，趋化因子表达和细胞因子网络的多参数分析。

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The contribution of IL-4 and IL-13 to inflammation and cytokine responses was compared in mice with types-1 or -2 pulmonary granulomas (GR) elicited by beads bound to antigens of Mycobacteria bovis (PPD) or Schistosoma mansoni eggs (SEA). Type-2 SEA-GR produced the most IL-4 and IL-13. Type-1 PPD-GR produced detectable IL-13, but not IL-4. Mice were treated with anti-IL4 or anti-IL-13 Abs, then lesion size/composition, cytokine/chemokine mRNA and lymph node cytokines were measured. Type-1 GRs resisted individual Abs, but combined Abs augmented lesions by 20%. In contrast, anti-IL-4 abrogated type-2 GR by 30-40% and eosinophil recruitment by 60%. Anti-IL-13 abrogated type-2 GR by 20-30% with no effect on eosinophils. Combined depletion reduced lesion area by 60% and eosinophils by more than 80%. In type-1 GR lungs, anti-IL-4 and anti-IL-13 augmented IFNgamma and TNFalpha mRNA. In type 2 lungs, anti-IL-13 did likewise, but anti-IL-4 decreased TNFalpha without affecting IFNgamma mRNA. In both responses, IL-4 promoted MCP-1 and MCP-5 mRNA, but IL-13 inhibited chemokines in type-1 GR. In lymph nodes, anti-IL-4, but not anti-IL-13, abrogated type-2 cytokines. In fact, IL-13 down-regulated itself and other type-2 cytokines. In summary, IL-4 and IL-13 have common and disparate regulatory functions in types 1 and 2 responses.
机译：比较了与牛分枝杆菌（PPD）或曼氏血吸虫卵抗原结合的磁珠引发的1型或-2型肺肉芽肿（GR）小鼠中IL-4和IL-13对炎症和细胞因子应答的贡献。 。 2型SEA-GR产生最多的IL-4和IL-13。 1型PPD-GR产生可检测的IL-13，但未产生IL-4。用抗IL4或抗IL-13抗体治疗小鼠，然后测量病变大小/组成，细胞因子/趋化因子mRNA和淋巴结细胞因子。 1型GR抵抗个体Abs，但合并的Abs使病变增加20％。相反，抗IL-4使2型GR废除30-40％，嗜酸性粒细胞募集减少60％。抗IL-13使2型GR废除20-30％，对嗜酸性粒细胞无影响。联合耗竭可使病变面积减少60％，嗜酸性粒细胞减少80％以上。在1型GR肺中，抗IL-4和抗IL-13增强了IFNgamma和TNFalpha mRNA。在2型肺中，抗IL-13的作用相同，但抗IL-4降低TNFalpha而不影响IFNgamma mRNA。在这两种反应中，IL-4均能促进MCP-1和MCP-5 mRNA的表达，但IL-13会抑制1型GR的趋化因子。在淋巴结中，抗IL-4（而非抗IL-13）消除了2型细胞因子。实际上，IL-13下调了自身和其他2型细胞因子。总之，IL-4和IL-13在1型和2型反应中具有共同的和完全不同的调节功能。

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