Convergence of innate immunity and insulin resistance as evidenced by increased nucleotide oligomerization domain (NOD) expression and signaling in monocytes from patients with type 2 diabetes

ShinyA.; ReginB.; BalachandarV.; GokulakrishnanK.; MohanV.; BabuS.; BalasubramanyamM.

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Convergence of innate immunity and insulin resistance as evidenced by increased nucleotide oligomerization domain (NOD) expression and signaling in monocytes from patients with type 2 diabetes

机译：2型糖尿病患者单核细胞中核苷酸寡聚结构域（NOD）表达和信号转导的增加证明了先天免疫和胰岛素抵抗的融合

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Despite the well known role of nucleotide oligomerization domain (NOD) receptor proteins in innate immunity, their association with diabetes is less explored. Here we report the transcriptional level of NODs and their downstream molecular signatures in CD14+ monocytes from subjects with different grades of glucose tolerance. NOD1 and NOD2 mRNA expression were significantly up-regulated in monocytes from patients with type 2 diabetes (T2DM) and positively correlated with HOMA-IR and poor glycemic control. Patients with T2DM also exhibited increased monocyte activation markers (CD11b and CD36) and proinflammatory signals downstream of NOD (RIPK2 and NFκB) along with the increased circulatory levels of TNF-α and IL-6. In vitro stimulation of monocytes with NOD specific ligands-i-EDAP and MDP significantly up regulated the mRNA expression of NOD1 and NOD2 respectively in T2DM. Our study exposes up regulation of NODs in monocytes as an important component of inflammation and insulin resistance in patients with T2DM.

机译：尽管核苷酸寡聚结构域（NOD）受体蛋白在先天免疫中起着众所周知的作用，但它们与糖尿病的关系却鲜有研究。在这里，我们报告了来自不同糖耐量等级受试者的CD14 +单核细胞中NODs的转录水平及其下游分子标记。 NOD1和NOD2 mRNA表达在2型糖尿病（T2DM）患者的单核细胞中显着上调，并且与HOMA-IR和不良的血糖控制呈正相关。 T2DM患者还表现出单核细胞激活标志物（CD11b和CD36）增加和NOD下游的促炎信号（RIPK2和NFκB），以及TNF-α和IL-6的循环水平增加。用NOD特异性配体i-EDAP和MDP体外刺激单核细胞分别显着上调了T2DM中NOD1和NOD2的mRNA表达。我们的研究揭示了单核细胞中NOD的调控是T2DM患者炎症和胰岛素抵抗的重要组成部分。

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《Cytokine》 |2013年第2期|共7页
作者
ShinyA.; ReginB.; BalachandarV.; GokulakrishnanK.; MohanV.; BabuS.; BalasubramanyamM.;
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正文语种 eng
中图分类细胞生物学;
关键词
Inflammation; Innate immunity; Insulin resistance; Nucleotide oligomerization domain (NOD); Type 2 diabetes;

机译：炎症;先天免疫;胰岛素抵抗;核苷酸寡聚化域（NOD）;2型糖尿病;

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1. Convergence of innate immunity and insulin resistance as evidenced by increased nucleotide oligomerization domain (NOD) expression and signaling in monocytes from patients with type 2 diabetes [J] . ShinyA., ReginB., BalachandarV., Cytokine . 2013,第2期

机译：2型糖尿病患者单核细胞中核苷酸寡聚结构域（NOD）表达和信号转导的增加证明了先天免疫和胰岛素抵抗的融合
2. Differential expression and regulation of nuclear oligomerization domain proteins NOD1 and NOD2 in human endometrium: a potential role in innate immune protection and menstruation [J] . Anne E. King14 Andrew W. Horne1 Sabine Hombach-Klonisch23 J. I. Mason1 and Hilary O.D. Critchley1 Molecular Human Reproduction . 2009,第5期

机译：人子宫内膜中核寡聚域蛋白NOD1和NOD2的差异表达和调控：在先天性免疫保护和月经中的潜在作用
3. Differential expression and regulation of nuclear oligomerization domain proteins NOD1 and NOD2 in human endometrium: a potential role in innate immune protection and menstruation [J] . Anne E. King, Andrew W. Horne, Sabine Hombach Klonisch Molecular human reproduction. . 2009,第5a6期

机译：人子宫内膜中核寡聚化域蛋白NOD1和NOD2的差异表达和调控：在先天性免疫保护和月经中的潜在作用
4. Analyzing EEG signals under insulin-induced hypoglycemia in type 1 diabetes patients [C] . Nguyen Lien B., Nguyen Anh V., Ling Sai Ho, Annual Conference of Japanese Society for Medical and Biological Engineering;Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2013

机译：分析1型糖尿病患者胰岛素诱导的低血糖下的脑电信号
5. Convergence of innate immunity and insulin resistance as evidenced by increased nucleotide oligomerization domain (NOD) expression and signaling in monocytes from patients with type 2 diabetes [O] . Abhijit Shiny, Bhaskaran Regin, Venketesan Balachandar, -1

机译：2型糖尿病患者单核细胞中核苷酸寡聚结构域（NOD）表达和信号转导的增加证明了先天免疫和胰岛素抵抗的融合
6. Convergence of innate immunity and insulin resistance as evidenced by increased nucleotide oligomerization domain (NOD) expression and signaling in monocytes from patients with type 2 diabetes [O] . Shiny, A, Regin, B S, Balachandar, V, 2013

机译：2型糖尿病患者单核细胞中核苷酸寡聚结构域（NOD）表达和信号转导的增加证明了先天免疫和胰岛素抵抗的融合

Convergence of innate immunity and insulin resistance as evidenced by increased nucleotide oligomerization domain (NOD) expression and signaling in monocytes from patients with type 2 diabetes

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