...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Activation profile of CXCL8-stimulated neutrophils and aging
【24h】

Activation profile of CXCL8-stimulated neutrophils and aging

机译：CXCL8刺激的中性粒细胞的活化特性和衰老

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neutrophils are pivotal effector cells of innate immunity representing the first line of defense against aggression. They are the first cells to arrive at the site of the aggression, where they can directly eliminate the invading microorganisms. Their activation and recruitment into peripheral tissues is indispensable for host defense. With aging, there are alterations of the receptor by driven functions of human neutrophils as a decrease in the functional changes in signaling elicited by specific receptors, as CXCR1. We investigated the activation of neutrophils from elderly after the cells were cultivated with CXCL8. Although, CXCL8 induced elastase (ELA) secretion, data showed neither myeloperoxidase (MPO) activity nor production of IL-6, IL-10, GM-CSF by neutrophils from elderly compared with young individuals. On the other hand, in the presence of only LPS or LPS associated with CXCL8 neutrophils from elderly individuals, there were significant levels of IL-6, IL-10, GM-CSF but not MPO. These results indicate that neutrophils from elderly do not respond to CXCL8 stimulus, but they are activated by LPS to produce cytokines. However, MPO activity from elderly individuals was not different in the presence or absence of LPS and CXCL8. ? 2013 Elsevier Ltd.
机译：中性粒细胞是先天免疫的关键效应细胞，代表抵抗攻击的第一道防线。它们是最早到达侵袭部位的细胞，它们可以直接消灭入侵的微生物。它们的活化和募集到周围组织中对于宿主防御是必不可少的。随着年龄的增长，人类嗜中性粒细胞的驱动功能会改变受体，因为特定受体（如CXCR1）引起的信号传导功能变化的减少。我们研究了用CXCL8培养细胞后老年人中性粒细胞的活化。尽管CXCL8诱导了弹性蛋白酶（ELA）的分泌，但数据显示，与年轻人相比，老年人的中性粒细胞既没有髓过氧化物酶（MPO）活性，也没有产生IL-6，IL-10，GM-CSF。另一方面，在仅LPS或与老年个体的CXCL8嗜中性粒细胞相关的LPS存在下，IL-6，IL-10，GM-CSF水平显着升高，而MPO则没有。这些结果表明，老年人的中性粒细胞对CXCL8刺激无反应，但被LPS激活以产生细胞因子。但是，在有或没有LPS和CXCL8的情况下，老年人的MPO活性没有差异。 ？ 2013爱思唯尔有限公司

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号