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首页> 外文期刊>Cytokine >Human neutrophils produce IL-12, IL-10, PGE2 and LTB4 in response to Paracoccidioides brasiliensis. Involvement of TLR2, mannose receptor and dectin-1
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Human neutrophils produce IL-12, IL-10, PGE2 and LTB4 in response to Paracoccidioides brasiliensis. Involvement of TLR2, mannose receptor and dectin-1

机译：人类嗜中性粒细胞响应巴西副球菌产生IL-12，IL-10，PGE2和LTB4。 TLR2，甘露糖受体和dectin-1的参与

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摘要

The functions of phagocytic cells against pathogens are initiated by the interaction between membrane receptors and molecular structures which compose the cell wall of these microorganisms. Thus our study aimed to identify the neutrophil receptors involved in the recognition of different strains of Paracoccidioides brasiliensis and the consequent modulation of immune response through the production of cyto-kines and inflammatory mediators. Neutrophils did not produce TNF-alfa in response to both strains. However, these cells produce IL-12, mainly in response to Pb 265, with participation of TLR2 and dectin-1. These cells also produce L-10, whose levels were higher for Pb 18 with involvement of TLR2 and MR and only TLR2 for Pb 265. The production of PGE2 and LTB4 was detected similarly for the two strains. For PGE2, MR and dectin-1 were involved, while in relation to LTB4, none of them. In summary, we demonstrated that neutrophils have a dynamic role during host immune response to P. brasiliensis, since in addition to their role as effector cells of innate immunity; they have the capacity to modulate innate and adaptative immune response against this fungus by producing cytokines and lipidic mediators. This modulation may be toward a pro- or anti-inflammatory pattern in a dependence of P. brasiliensis strains and PRR involved in fungus recognition by these cells.
机译：吞噬细胞针对病原体的功能是由膜受体与组成这些微生物细胞壁的分子结构之间的相互作用而引发的。因此，我们的研究旨在鉴定嗜中性粒细胞受体，该嗜中性粒细胞受体参与了巴西副球菌的不同菌株的识别，并由此通过产生细胞因子和炎症介质来调节免疫应答。中性粒细胞对两种菌株均不产生TNF-α。但是，这些细胞主要在Pb 265的应答下产生TLR2和dectin-1参与的IL-12。这些细胞还产生L-10，其中Pb 18的水平较高，其中TLR2和MR参与，而PLR 265的水平仅为TLR2。这两种菌株的PGE2和LTB4的生成情况相似。对于PGE2，不涉及MR和dectin-1，而对于LTB4，均不涉及。总之，我们证明中性粒细胞在宿主对巴西假单胞菌的免疫反应中具有动态作用，因为它们除了具有先天免疫的效应细胞的作用外，还具有其他作用。它们具有通过产生细胞因子和脂质介体来调节针对这种真菌的先天性和适应性免疫反应的能力。依赖于巴西假单胞菌菌株和这些细胞参与真菌识别的PRR的依赖，这种调节可能趋向于促炎或抗炎模式。

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