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Pathophysiological mechanisms regulated by cytokines in gliomas

机译:胶质瘤中细胞因子调节的病理生理机制

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Glioma, a neuroglia originated malignancy, consists of one of the most aggressive primary tumors of the central nervous system with poor prognosis and lack of efficient treatment strategy. Cytokines have been implicated in several stages of glioma progression, participating in tumor onset, growth enhancement, angiogenesis and aggressiveness. Interestingly, cytokines have also the ability to inhibit glioma growth upon specific regulation or interplay with other molecules. This review addresses the dual role of major cytokines implicated in glioma pathology, pointing toward promising therapeutic approaches. (C) 2014 Elsevier Ltd. All rights reserved.
机译:胶质瘤是神经胶质起源的恶性肿瘤,由中枢神经系统最具侵略性的原发性肿瘤之一组成,预后较差且缺乏有效的治疗策略。细胞因子已牵涉到神经胶质瘤进展的多个阶段,参与肿瘤发作,生长增强,血管生成和侵袭性。有趣的是,细胞因子还具有在特定调节或与其他分子相互作用时抑制神经胶质瘤生长的能力。这篇综述针对神经胶质瘤病理学中涉及的主要细胞因子的双重作用,指出了有希望的治疗方法。 (C)2014 Elsevier Ltd.保留所有权利。

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