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首页> 外文期刊>Cytokine >Elevated IL-3 and IL-12p40 levels in the lower airway of infants with RSV-induced bronchiolitis correlate with recurrent wheezing
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Elevated IL-3 and IL-12p40 levels in the lower airway of infants with RSV-induced bronchiolitis correlate with recurrent wheezing

机译：RSV诱发的细支气管炎婴儿下呼吸道中IL-3和IL-12p40水平升高与反复喘息相关

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摘要

Respiratory Syncytial Virus (RSV) is the first cause of hospitalization due to bronchiolitis in infants. RSV bronchiolitis has been linked to asthma and recurrent wheezing, however the mechanisms behind this association have not been elucidated. Here, we evaluated the cytokine and chemokine profiles in the airways in infants with RSV bronchiolitis. Nasopharyngeal Aspirates (NPA) and Bronchoalveolar Lavage Fluids (BALF) from infants hospitalized due to RSV bronchiolitis and healthy controls were analyzed for cytokine and chemokine production. We observed elevated levels of Th2 cytokines (IL-3, IL-4, IL-10 and IL-13), pro-inflammatory cytokines and chemokines (IL-1 beta, IL-6, TNF-beta, MCP-1/CCL2, MIP-1 alpha/CCL3 and IL-8/CXCL8) in BALF from infants with RSV bronchiolitis, as compared to controls. We found a direct correlation of IL-3 and IL-12p40 levels with the development of recurrent wheezing later in life. These results suggest that IL-3 and IL-12p40 could be considered as molecular predictors for recurrent wheezing due to RSV infection. (C) 2015 Elsevier Ltd. All rights reserved.
机译：呼吸道合胞病毒（RSV）是婴儿毛细支气管炎导致住院的首个原因。 RSV毛细支气管炎与哮喘和反复喘息有关，但是尚未阐明这种关联的机制。在这里，我们评估了RSV细支气管炎婴儿的气道中的细胞因子和趋化因子谱。对因RSV细支气管炎住院的婴儿鼻咽抽吸物（NPA）和支气管肺泡灌洗液（BALF）进行了分析，并分析了健康对照组的细胞因子和趋化因子的产生。我们观察到Th2细胞因子（IL-3，IL-4，IL-10和IL-13），促炎性细胞因子和趋化因子（IL-1 beta，IL-6，TNF-beta，MCP-1 / CCL2）水平升高与对照组相比，来自RSV细支气管炎婴儿的BALF中的MIP-1α/ CCL3和IL-8 / CXCL8）。我们发现IL-3和IL-12p40水平与晚年复发性喘息的发展有直接关系。这些结果表明，IL-3和IL-12p40可以被认为是由于RSV感染引起的反复喘息的分子预测因子。 （C）2015 Elsevier Ltd.保留所有权利。

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