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Host factors associated with serologic inflammatory markers assessed using multiplex assays

机译：使用多重分析评估与血清炎症标志物相关的宿主因子

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Chronic systemic inflammation contributes to the development of adverse health conditions, yet the influence of fixed and modifiable risk factors on many serologic biomarkers of inflammation remains largely unknown. Serum concentrations of twenty-three biomarkers, including C-reactive protein (CRP), cytokines (CXCL11, CXCL8, CXCL10, CCL2, CCL13, CCL4, CCL17, CXCL13, IL-10, IL-12p70, IL-6, TNF-alpha, IL-2, IFN-gamma, IL-1 beta, GM-CSF, BAFF), and soluble immune receptors (5CD14, sIL-2R alpha, sCD27, sgp130, sTNF-R2) were measured longitudinally using multiplexed immunometric assays in 250 HIV-uninfected men followed in the Multicenter AIDS Cohort Study (1984-2009). Generalized gamma regression was used to determine the statistical significance of factors associated with each biomarker. After accounting for age, race, and education, and for analysis of multiple biomarkers, higher concentrations of specific individual biomarkers were significantly (P < 0.002) associated with hypertension, obesity, hepatitis C infection, stimulant use, and diabetes and lower concentrations with hypercholesterolemia. These associations should be taken into account in epidemiological studies of these biomarkers, and may provide potential targets for disease prevention and treatment. (C) 2016 Elsevier Ltd. All rights reserved.
机译：慢性全身性炎症助长了不利健康状况的发展，但是固定的和可改变的危险因素对炎症的许多血清学生物标志物的影响仍然未知。血清中23种生物标志物的浓度，包括C反应蛋白（CRP），细胞因子（CXCL11，CXCL8，CXCL10，CCL2，CCL13，CCL4，CCL17，CXCL13，IL-10，IL-12p70，IL-6，TNF-alpha ，IL-2，IFN-γ，IL-1 beta，GM-CSF，BAFF）和可溶性免疫受体（5CD14，sIL-2R alpha，sCD27，sgp130，sTNF-R2）在250个样品中进行了多重免疫测定未感染艾滋病毒的男性参与了多中心艾滋病队列研究（1984-2009）。使用广义伽马回归来确定与每个生物标记物相关的因素的统计学意义。在考虑了年龄，种族和教育程度，并分析了多种生物标志物后，较高的特定个体生物标志物浓度与高血压，肥胖，丙型肝炎感染，兴奋剂和糖尿病相关（P <0.002），而低胆固醇血症。在这些生物标记物的流行病学研究中应考虑这些关联，并可能为疾病的预防和治疗提供潜在的靶标。 （C）2016 Elsevier Ltd.保留所有权利。

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