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首页> 外文期刊>Cytokine >Circulating levels of adipocytokine omentin-1 in patients with renal cell cancer
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Circulating levels of adipocytokine omentin-1 in patients with renal cell cancer

机译：肾细胞癌患者脂联素omentin-1的循环水平

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Renal cell carcinoma (RCC) is the fifth most common cancer worldwide, and becomes one of the leading causes of genitourinary cancer-related death in both males and females. Genetic alternations, alcohol consumption, occupationally harmful exposure and even obesity are well-established risk factors of RCC. Omentin-1 is a plasma adipokine synthesized in visceral adipose tissue, and its circulating serum concentration alters not only in conditions associated with insulin resistance such as Polycystic Ovary Syndrome (PCOS), but also in colorectal cancer and prostate cancer. To our best knowledge, the relationship between omentin-1 and RCC has not been clarified previously. Thus, we evaluated serum omentin-1 levels in RCC patients in the current matched case-control study. Forty-one patients newly diagnosed with RCC and forty-two healthy controls confirmed by the comprehensive medical examination were assessed. The omentin-1 concentrations were determined via utilizing enzyme-linked immunosorbent assays (ELISA) in the paired groups, in which the patients and healthy controls had no statistically significant differences in gender, age, systolic blood pressure (SBP), diastolic blood pressure (DBP), waist-hip ratio (WHR), estimate glomerular filtration rate (eGFR), body-mass index (BMI) and biochemical parameters. The omentin-1 levels in healthy people were 9.86 +/- 1.44 ng/mL and the circulating omentin-1 levels were dramatically decreased to 3.62 +/- 0.76 ng/mL in RCC patients (p < 0.001). Besides, we revealed a negative correlation between omentin-1 with WHR (r= -0.261, p = 0.017) and BMI (r= 0.310, p = 0.004), further indicating BMI was the main influential factor on omentin-1 levels (p 0.0091). Follow-up studies would be conducted to establish the concrete mechanisms underlying the altered circulating levels of omentin-1 and elucidate the interaction between "RCC complex system" and adipose tissues, which may together provide promising and novel pharmacological insights for RCC theragnosis in the near future. (C) 2015 Elsevier Ltd. All rights reserved.
机译：肾细胞癌（RCC）是全球第五大最常见的癌症，并且成为男性和女性与泌尿生殖道癌相关死亡的主要原因之一。遗传变异，饮酒，职业有害暴露甚至肥胖是RCC公认的危险因素。 Omentin-1是在内脏脂肪组织中合成的血浆脂肪因子，其循环血清浓度不仅在与胰岛素抵抗相关的疾病（如多囊卵巢综合征（PCOS））中发生变化，而且在结直肠癌和前列腺癌中也发生变化。据我们所知，omentin-1与RCC之间的关系以前尚未阐明。因此，我们在当前匹配的病例对照研究中评估了RCC患者的血清omentin-1水平。评估了41例新诊断为RCC的患者和42例经过全面医学检查确认的健康对照。通过配对酶联免疫吸附测定（ELISA）确定omentin-1的浓度，其中患者和健康对照组在性别，年龄，收缩压（SBP），舒张压方面无统计学差异（ DBP），腰臀比（WHR），估计肾小球滤过率（eGFR），身体质量指数（BMI）和生化参数。健康人中omentin-1的水平为9.86 +/- 1.44 ng / mL，RCC患者的循环中omentin-1的水平显着降低至3.62 +/- 0.76 ng / mL（p <0.001）。此外，我们发现omentin-1与WHR（r = -0.261，p = 0.017）和BMI（r = 0.310，p = 0.004）之间呈负相关，进一步表明BMI是影响omentin-1水平的主要因素（p 0.0091）。将进行后续研究，以建立omentin-1循环水平改变背后的具体机制，并阐明“ RCC复杂系统”与脂肪组织之间的相互作用，这可能会为近来的RCC鼻疽病提供有希望的和新颖的药理学见解。未来。 （C）2015 Elsevier Ltd.保留所有权利。

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