• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research bulletin >Hippocampal theta rhythm induced by vagal nerve stimulation: The effect of modulation of electrical coupling
【24h】

Hippocampal theta rhythm induced by vagal nerve stimulation: The effect of modulation of electrical coupling

机译：迷走神经刺激诱导的海马θthya节奏：电耦合调制的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previously we have demonstrated that vagal nerve stimulation (VNS) is capable of inducing hippocampal formation (HPC) theta rhythm (Broncel et al., 2017). The neuronal substrate underlying this novel phenomenon is poorly known, though the cholinergic and GABAergic profile of VNS-induced theta rhythm in anesthetized rats has just recently been addressed (Broncel et al., 2018a, 2019). In this study we extended our earlier observation concerning the pharmacological profile of VNS-induced theta oscillations. Specifically, the purpose of the present study was to test the hypothesis that VNS-induced hippocampal theta rhythm could be modulated by local HPC gap junctions (GJs) transmission. Two GJs agents were used: carbenoxolone, nonspecific GJs blocker and trimethylamine, a nonspecific opener of GJs. Two basic parameters of theta rhythm were evaluated: frequency and power. It was demonstrated that carbenoxolone inhibits VNS-induced theta while trimethylamine facilities it. These observations indicate that HPC electrical coupling mediates the theta rhythm induced by vagal nerve stimulation.
机译：以前我们已经证明迷进神经刺激（VNS）能够诱导海马形成（HPC）θthea节奏（Broocel等，2017）。刚才已知这种新颖现象的神经元基质是众所周知的，尽管刚刚解决了VNS诱导的大鼠中的胆碱能和GABA能谱（Broocel等，2018年，2019）。在这项研究中，我们延长了我们早期的观察，关于VNS诱导的θ振荡的药理学谱。具体地，本研究的目的是测试VNS诱导的海马Theta节律的假设可以通过局部HPC间隙结（GJS）透射来调节。使用了两种GJS药剂：碳氧酮，非特异性GJS阻滞剂和三甲胺，GJS的非特异性开启者。评估了θ节奏的两个基本参数：频率和功率。据证明，碳氧基酮抑制VNS诱导的θ，同时三甲胺设施。这些观察结果表明，HPC电耦合介导迷走神经刺激诱导的θ节奏。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号