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首页> 外文期刊>British Journal of Haematology >Multiple unit umbilical cord blood transplantation with total body irradiation, etoposide and antithymocyte globulin for adult haematological malignancy patients.
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Multiple unit umbilical cord blood transplantation with total body irradiation, etoposide and antithymocyte globulin for adult haematological malignancy patients.

机译:具有全身照射,依托磷脂和抗肾小球球蛋白的多单位脐带血,成人血液恶性肿瘤患者。

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摘要

Allogeneic haematopoietic progenitor cell transplantation(HPCT) is a potentially curative treatment for haematologicalmalignancy patients. However, many patients who couldbenefit from this therapy lack a suitable human leucocyteantigen (HLA)-matched donor. Umbilical cord blood (UCB) isan alternative donor source that has been used to reestablishhaematopoiesis after transplant (Kurtzberg et al, 1996). UCBtransplantation (UCBT) has often been performed with !2HLA disparities (Laughlin et al, 2001) and has resulted in lessacute and less extensive chronic graft-versus-host disease(GVHD) than that observed with conventional allogeneicHPCT (Kurtzberg et al, 1996).
机译:同种异体造血祖细胞移植(HPCT)是血良性患者的潜在治疗方法。 然而,许多难以从这种治疗的患者缺乏合适的人类白细胞(HLA) - 配送剂。 脐带血(UCB)ISAN替代供体来源,用于在移植后被用于重新布解Haematopoiesis(Kurtzberg等,1996)。 UCBTransprantation(UCBT)经常使用!2HLA差异(Laughlin等,2001),并导致持常规同种异体(Kurtzberg等人,1996)所观察到的持久性和慢性慢性移植术 - 宿主病(GVHD) 。

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