• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>British journal of ophthalmology >Long-term follow-up of quiescent choroidal neovascularisation associated with age-related macular degeneration or pachychoroid disease
【24h】

Long-term follow-up of quiescent choroidal neovascularisation associated with age-related macular degeneration or pachychoroid disease

机译：与年龄相关的黄斑变性或嗜弹性脉络膜疾病相关的静止脉络膜新生血管的长期随访

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To evaluate the long-term progression of quiescent type 1 choroidal neovascularisation (CNV) associated with age-related macular degeneration (AMD) or with pachychoroid disease.All cases of quiescent type 1 CNV with a minimum follow-up of 12 months seen at the Department of Ophthalmology of University Paris Est, Creteil and at the Centre Ophtalmologique de l’Odeon, Paris, between June 2009 and December 2018 were retrospectively reviewed. Optical coherence tomography angiography (OCT-A) of eyes not showing CNV activation during 24 months was evaluated for quantitative analyses of CNV status biomarkers (fractal dimension, lacunarity, vessel density, aspect ratio, CNV area).A total of 67 eyes (65 patients, 43 females, mean age 76.63±9.7 years) with quiescent CNV and a mean follow-up of 49.56±27.3 (12–112) months were included. Of 28 eyes showing activation of quiescent CNV, 12 eyes with pachychoroid-associated CNV showed reduced visual loss (?3.28 ETDRS letters, p=0.7 vs ?13.03 ETDRS letters, p=0.02), greater choroidal thinning (?59.5?μm, p=0.03?vs – 16.36?μm, p=0.3) and needed less antivascular endothelial growth factor intravitreal injections (IVI) (0.09 vs 0.21, p=0.01) than 16 eyes with AMD-associated CNV. CNV area was the only OCT-A biomarker to significantly change during 24 months in inactive quiescent CNV (+29.5%, p=0.01, in pachychoroid group and +27.1%, p=0.03, in the AMD group).In the long-term follow-up, inactive quiescent CNV showed an increase of CNV area without significant changes of the other OCT-A biomarkers. Quiescent type 1 CNV undergoing activation showed greater response to IVI when associated to pachychoroid.
机译：为了评估与年龄相关的黄斑变性（AMD）或嗜弹性性黄斑（AMD）相关的静止态型1个脉络膜新生血管体外（CNV）的长期进展。静态型1型CNV的案例，最低后续6个月回顾性地审查了Paris Est，Creteil，Creteil，Creteil和Centhe Ophtalmologique de L'Odeon中心Ophtalmologique de L'Odeon的部门。在24个月内未显示CNV激活的眼睛的光学相干断层造影血管造影（OCT-A）对于CNV状态生物标志物（分形尺寸，姿势，血管密度，纵横比，CNV面积）的定量分析。总共67只眼睛（65患者，43名女性，平均值76.63±9.7岁），包括49.56±27.3（12-112）个月的平均随访。 28只眼睛显示静止CNV的激活，12只眼睛具有嗜慢性相关的CNV，表现出视觉损失减少（？3.28 ETDRS字母，P = 0.7 VS？13.03 ETDRS字母，P = 0.02），更大的脉络膜稀释（？59.5？μm，p = 0.03？vs - 16.36？μm，p = 0.3），并且需要较低的抗血管内皮生长因子玻璃体内注射（IVI）（0.09 Vs 0.21，p = 0.01），具有AMD相关的CNV。 CNV地区是唯一的八月生物标志物，在非活性静态CNV（+ 29.5％，P = 0.01，在糖胆碱组中，+ 27.1％，P = 0.03，在AMD组中的24个月内显着变化）。在长期 - 术语随访，无活性静态CNV显示CNV区域的增加，而没有其他OCT-A生物标志物的显着变化。静态类型1 CNV接受激活显示与杆菌类oid相关时对IVI的更大响应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号