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首页> 外文期刊>British journal of ophthalmology >Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes
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Repeatability and comparability of peripapillary vessel density measurements of high-density and non-high-density optical coherence tomography angiography scans in normal and glaucoma eyes

机译：高密度和非高密度光学相干断层血管造影血管扫描在正常和青光眼的血管血管密度测量的可重复性和可比性

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Aims To compare the peripapillary vessel density (VD) measurements of high-density (HD) and non-HD optical coherence tomography angiography (OCTA) scans in normal and glaucoma eyes, and to evaluate the intrasession repeatability of VD measurements of HD scans. Methods In a cross-sectional study, 46 normal (33 subjects) and 89 glaucoma (64 patients) eyes underwent 3 HD and 1 non-HD optic nerve head OCTA scans in the same session. Agreement in VD measurements between HD and non-HD scans was assessed using Bland and Altman analysis. Repeatability of the VD measurements of HD scans was assessed using within-subject coefficient of repeatability (CRw) and variation (CVw). Results The mean difference in the VDs ranged between 0.7% (temporal sector VD) and 2.0% (inferonasal sector VD), with HD scans showing significantly greater VD values than non-HD scans. The 95% limits of agreement (LoA) in glaucoma eyes ranged between -2.0% and 5.0% for whole enface VD and between -4.8% and 9.6% for superotemporal VD. CRw (%) and CVw (%) of VD measurements of HD scans ranged from 3.0 to 4.9 and from 2.0 to 3.1 in normal eyes. The same ranged from 3.2 to 6.7 and from 2.6 to 4.8, respectively, in glaucoma eyes. Conclusions VD of HD scans was higher than that of non-HD scans. The wide 95% LoA indicates that the VD measurements of HD and non-HD scans cannot be used interchangeably. Test-retest repeatability of VDs on HD scans was as high as 6%. These results should be considered while using OCTA for longitudinal evaluation of glaucoma.
机译：旨在比较正常和青光眼眼中高密度（HD）和非高清光学相干断层血管造影（OctA）扫描的围毛绒血管密度（VD）测量，并评估高清扫描的VD测量的血液血液重复性。方法在横截面研究中，46例正常（33个受试者）和89例青光眼（64名患者）眼睛在同一届会议上进行了3 HD和1个非高清视神经头Octa扫描。使用Bland和Altman分析评估高清和非高清扫描之间的VD测量的协议。使用在受试者内部可重复性（CRW）和变化（CVW）内进行评估HD扫描VD测量的可重复性。结果VDS的平均差异范围为0.7％（时间扇形VD）和2.0％（差异扇区VD），HD扫描显示出比非高清扫描的VD值明显更大。荧光眼眼中的95％协议限制（LOA）的极限范围为-2.0％和5.0％，对于超时Vd的-4.8％和9.6％之间。 HD扫描VD测量的CRW（％）和CVW（％）的VD测量范围为3.0至4.9，正常眼中2.0至3.1。相同的范围从3.2到6.7分别在青光眼的眼中分别为2.6至4.8。结论高清扫描的VD差距高于非高清扫描。宽95％的LOA表示HD和非高清扫描的VD测量不能互换使用。 HD扫描上VDS的测试重复可重复性高达6％。在使用Octa用于纵向评估青光眼的同时应考虑这些结果。

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