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首页> 外文期刊>British journal of ophthalmology >Antibodies to myelin oligodendrocyte glycoprotein in chronic relapsing inflammatory optic neuropathy
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Antibodies to myelin oligodendrocyte glycoprotein in chronic relapsing inflammatory optic neuropathy

机译：对霉菌蛋白寡替肽胶质细胞糖蛋白的抗体在慢性复发炎症视神经病变中

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摘要

To evaluate the status of myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) in chronic relapsing inflammatory optic neuropathy (CRION) and investigate its different clinical characteristics and prognosis.Patients diagnosed with CRION were recruited by the Neuro-ophthalmology Department of the Chinese People9s Liberation Army General Hospital from December 2015 to April 2017. Based on antibody status, they were assigned to either the MOG-CRION or seronegative-CRION groups.A total of 33 patients (38 eyes) were assessed and divided into the following groups: 22 (66.7%) MOG-CRION and 11 (33.3%) seronegative-CRION. The ratio of female to male was 1:1, and 81.8% of total CRION patients were adults (e18 years). A total of 29 eyes (76.3%) showed severe visual loss ( 20/40) during the final follow-up. The mean onset age of MOG-CRION patients was 28 ?16 years (range 662), which was significantly younger than that of seronegative-CRION (45 ?12 years, range 2259) (p=0.029). The intraorbital and canalicular segments were highly involved in the orbital MRI of CRION patients. During the final follow-up, MOG-CRION patients had more bilateral involvement (p=0.008) and higher annualised relapse rates compared with the seronegative-CRION patients (p=0.019).CRION was predominantly found in adults with unilateral ON and exhibited a higher rate of seropositive MOG-IgG. MOG-CRION, which may be a disparate subtype of MOG-IgG-induced demyelinating disease that needs further investigation, was found in younger patients at onset, with more bilateral involvement and more relapse tendency.
机译：评估慢性复发炎症视神经病变（rion）中霉菌素寡核细胞糖蛋白抗体（MOG-IgG）的状态，并研究其不同临床特征和预后。中国人民9S解放军神经眼科署患有克隆的患者综合医院从2015年12月到2017年4月。根据抗体状态，分配给沼泽rion或血清潜力群组。评估33例患者（38只眼），并分为以下组：22（66.7 ％）莫氏植物和11（33.3％）血清可Gious。女性对男性的比例为1：1，81.8％的rikion患者是成人（E18年）。总共29只眼（76.3％）在最终随访期间显示出严重的视觉损失（20/40）。萌芽患者的平均发病年龄为28岁（662），比苏酮导码（45〜12岁，范围为2259），（P = 0.029）显着较小。胎疽性和穴位段高度涉及克隆患者的眶段。在最后的随访期间，与苏酮群患者相比，莫氏群患者具有更多双侧受累（p = 0.008）和更高的年化复发率（p = 0.019）。群体主要在成年人中发现，并展出了一个单边的成年人血清阳性莫氏液率较高。莫氏群，可能是疗法诱导的脱髓鞘疾病的不同亚型，在发病的较年轻患者中发现了进一步调查的脱髓鞘疾病，具有更多双侧受累和更复发倾向。

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