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首页> 外文期刊>Cytokine >Interleukin-21 mRNA expression during virus infections.
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Interleukin-21 mRNA expression during virus infections.

机译：病毒感染期间白介素21 mRNA表达。

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摘要

Interleukin-21 is a cytokine with profound impact on the proliferation and differentiation of activated leukocytes of both the innate and adaptive immune system. In experiments in vitro, antigen activation induces IL-21 production in CD4+ T cells. Where, when, and how the proliferative and activational effects of IL-21 on different leukocytes come into play in vivo in an immune response has so far not been fully investigated. We show here for the first time in vivo, that IL-21 mRNA is produced in the spleen when mice are challenged with herpes simplex virus type 2 (HSV-2) or lymphocytic choriomeningitis virus (LCMV). We show in HSV-2 challenged mice that this production takes place in CD4+ T cell fractions and is absent in CD4+ T cell-depleted fractions. We also show that the peak of IL-21 mRNA production in both the HSV-2 and LCMV-challenged mice coincides with the onset of the adaptive immune response. Thus, our data suggest a role for IL-21 in the early stages of adaptive immune response against virus infections.
机译：白介素-21是一种细胞因子，对先天和适应性免疫系统的活化白细胞的增殖和分化都有深远的影响。在体外实验中，抗原激活诱导CD4 + T细胞中IL-21的产生。迄今为止，尚未完全研究IL-21对不同白细胞的增殖和活化作用在体内在免疫应答中的作用。我们在这里首次在体内显示，当小鼠受到2型单纯疱疹病毒（HSV-2）或淋巴细胞性脉络膜脑膜炎病毒（LCMV）攻击时，脾脏中会产生IL-21 mRNA。我们在受HSV-2攻击的小鼠中显示，这种产生发生在CD4 + T细胞组分中，而在CD4 + T细胞缺失的组分中不存在。我们还显示，在HSV-2和LCMV攻击的小鼠中IL-21 mRNA产生的峰值与适应性免疫反应的发生相吻合。因此，我们的数据表明IL-21在针对病毒感染的适应性免疫应答的早期阶段中发挥了作用。

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