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首页> 外文期刊>Cytokine >Immune status evaluation of patients with chronic heart failure.
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Immune status evaluation of patients with chronic heart failure.

机译：慢性心力衰竭患者的免疫状态评估。

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Chronic heart failure (CHF) may be considered a state of immune activation and persistent inflammation expressed by increased circulating levels of pro- and anti-inflammatory cytokines. The purpose of the study was to investigate the immune status in patients with CHF compared to normal individuals. We measured serum cytokine levels as well as cytokine production after ex vivo LPS stimulation of whole blood taken from 14 patients with CHF and 14 healthy volunteers. We used 500 pg/ml of LPS for an incubation period of 4h to stimulate 100 microL of whole blood. Patients with CHF had significantly higher levels of TNF-RI, and TNF-RII in serum compared to normal individuals. TNF-alpha, IL-6, and IL-10 did not differ significantly. After LPS stimulation, patients with CHF had significantly higher levels of TNF-alpha and IL-10, and significantly lower IL-6 levels compared to normal individuals. TNF-alpha receptors did not differ significantly. Patients with CHF may be found in a pro- as well as an anti-inflammatory state. They also do not develop endotoxin tolerance in an ex vivo laboratory model using whole blood stimulated with LPS. They may have increased TNF-alpha and IL-10 production after LPS stimulation of whole blood, which may contribute to a worsening of heart function, more severe disease presentation and a worse outcome during infections.
机译：慢性心力衰竭（CHF）可以被认为是免疫激活和持续炎症的状态，其表现为促炎和抗炎细胞因子的循环水平增加。这项研究的目的是调查CHF患者与正常人相比的免疫状况。我们测量了从14位CHF患者和14位健康志愿者获得的全血离体LPS刺激后的血清细胞因子水平以及细胞因子产生。我们使用500 pg / ml的LPS孵育4小时，以刺激100微升全血。与正常人相比，患有CHF的患者血清中的TNF-RI和TNF-RII水平显着更高。 TNF-α，IL-6和IL-10没有显着差异。 LPS刺激后，与正常人相比，CHF患者的TNF-α和IL-10水平明显升高，而IL-6水平则明显降低。 TNF-α受体无显着差异。 CHF患者可能处于促发状态和消炎状态。在使用LPS刺激的全血的离体实验室模型中，它们也不会产生内毒素耐受性。 LPS刺激全血后，它们可能会增加TNF-α和IL-10的产生，这可能导致心脏功能恶化，疾病表现更为严重以及感染期间的预后恶化。

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