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首页> 外文期刊>Cytokine >Influence of the IL-6 -572C>G polymorphism on inflammatory markers according to cigarette smoking in Korean healthy men.
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Influence of the IL-6 -572C>G polymorphism on inflammatory markers according to cigarette smoking in Korean healthy men.

机译：IL-6 -572C> G多态性对韩国健康男性吸烟后炎症标志物的影响。

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We investigated whether smoking would interact with the interleukin-6 (IL-6) polymorphisms (-174G>C and -572C>G, -597G>A and -1363G>T) in determining circulating levels of inflammatory markers and its consequence to oxidative stress. The G/G genotype (n=26) of the -572C>G in nonsmokers (n=376) was associated with higher IL-6 (P=0.028), fibrinogen (P=0.007) and ox-LDL (P=0.006) than those with C/C (n=209) or C/G (n=141). Results were similar for nonsmokers and smokers (n=268), but in smokers, the -572G/G genotype was associated with a greater difference in levels of IL-6 (P=0.031), fibrinogen (P=0.001), ox-LDL (P=0.037) and PGF(2alpha) (P=0.050). IL-6 had positive relations with CRP, fibrinogen, ox-LDL and PGF(2alpha). There was no evidence of an effect of -572C>G genotype on CRP levels in nonsmokers, however, this polymorphism was associated with a highly significant effect on CRP in smokers (P<0.001) (genotype-smoking interaction P=0.04, adjusted for age, BMI and IL-6). The C allele frequency at the -174 promoter region of IL-6 was very rare (<0.01) and -597G>A and -1363G>T were monomorphic in this study. Our results suggest that IL-6 -572C>G has a greater response over time to the inflammatory effects of smoking and this may result in smokers having higher oxidative stress in subjects with G/G compared to C/C or C/G.
机译：我们研究了吸烟是否会与白细胞介素6（IL-6）多态性（-174G> C和-572C> G，-597G> A和-1363G> T）相互作用，从而确定炎症标志物的循环水平及其对氧化的影响强调。非吸烟者（n = 376）中-572C> G的G / G基因型（n = 26）与较高的IL-6（P = 0.028），纤维蛋白原（P = 0.007）和ox-LDL（P = 0.006）相关），而不是C / C（n = 209）或C / G（n = 141）。非吸烟者和吸烟者的结果相似（n = 268），但是在吸烟者中，-572G / G基因型与IL-6（P = 0.031），纤维蛋白原（P = 0.001），ox- LDL（P = 0.037）和PGF（2alpha）（P = 0.050）。 IL-6与CRP，纤维蛋白原，ox-LDL和PGF（2alpha）呈正相关。没有证据表明-572C> G基因型对不吸烟者的CRP水平有影响，但是，这种多态性与吸烟者对CRP的高度显着影响有关（P <0.001）（基因型-吸烟相互作用P = 0.04，针对年龄，BMI和IL-6）。在本研究中，IL-6 -174启动子区域的C等位基因频率非常罕见（<0.01），-597G> A和-1363G> T是单态的。我们的结果表明，随着时间的推移，IL-6 -572C> G对吸烟的炎症作用具有更大的响应，与C / C或C / G相比，G / G的受试者可能导致吸烟者具有更高的氧化应激。

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