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首页> 外文期刊>Cytokine >TGF-beta(1) gene polymorphism in psoriasis vulgaris.
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TGF-beta(1) gene polymorphism in psoriasis vulgaris.

机译：寻常型牛皮癣的TGF-beta（1）基因多态性。

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摘要

Overexpression of TGF-beta(1) has been implicated in the pathology of many inflammatory diseases, including psoriasis. This study was performed to investigate the association between TGF-beta(1) single nucleotide polymorphism and susceptibility for psoriasis vulgaris. DNA from 78 patients with psoriasis vulgaris and 74 healthy volunteers was investigated. Polymorphism of TGF-beta(1) gene in codon 10 (T/C) and codon 25 (G/C) was evaluated by PCR-SSP and the results were compared between group of psoriatic patients, divided into early onset of psoriasis (type I) and late onset of psoriasis (type II) subgroups, and control healthy subjects. Frequencies in genotypes were similar between patients and control group (p >0.7), but between type I and type II psoriasis patients highly significant difference was found (p <0.0003). Higher frequency of CC/GG (intermediate producer) and TC/GG (high producer) was noted in the type I group, but the second high producer genotype (TT/GG) was more common in type II group. Also between type II psoriasis patients and healthy controls statistically significant difference was found (p <0.000001). In analyzing frequencies of carriage and alleles no significant differences were found. TGF-beta(1) gene polymorphism in codon 10 and 25 is not associated with susceptibility to psoriasis vulgaris, but may be important for the type of the disease.
机译：TGF-beta（1）的过度表达已牵涉到许多炎性疾病（包括牛皮癣）的病理中。进行这项研究以调查TGF-beta（1）单核苷酸多态性与寻常型牛皮癣的易感性之间的关联。研究了来自78名寻常型牛皮癣患者和74名健康志愿者的DNA。通过PCR-SSP评估10号密码子（T / C）和25号密码子（G / C）中TGF-beta（1）基因的多态性，并比较银屑病患者各组的结果，分为银屑病的早期发作（类型I）和牛皮癣（II型）亚组的晚期发作，并控制健康受试者。患者和对照组之间的基因型频率相似（p> 0.7），但是在I型和II型牛皮癣患者之间发现了高度显着的差异（p <0.0003）。 I型组中CC / GG（中间生产者）和TC / GG（高产者）的发生率较高，但第二高生产者基因型（TT / GG）在II型组中更为常见。在II型牛皮癣患者和健康对照之间也发现了统计学上的显着差异（p <0.000001）。在分析运输和等位基因的频率时，未发现显着差异。 TGF-beta（1）基因密码子10和25中的多态性与寻常型牛皮癣的易感性无关，但可能对疾病的类型很重要。

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