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首页> 外文期刊>Cytokine >Sustained biological effects of porcine interleukin 5 delivered to pigs as recombinant protein or via a DNA vector.
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Sustained biological effects of porcine interleukin 5 delivered to pigs as recombinant protein or via a DNA vector.

机译：猪白介素5作为重组蛋白或通过DNA载体传递给猪的持续生物学效应。

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The ability of cytokines to act as natural immunotherapeutics to enhance the health and the disease resistance of animals is of particular interest to the intensive livestock industries. Antibiotics have been used for such purposes over a long period of time, however, there is growing concern that this practice will enhance the development of antibiotic resistance in a range of bacterial pathogens. In several species, interleukin 5 (IL-5) is known to enhance B cell activity and to increase the numbers of eosinophils in blood and tissues. In this report, IL-5 was delivered to pigs, either as a recombinant protein or via a DNA delivery vector and was shown to elevate eosinophils in blood over a sustained period. Interleukin 3, a potent haemopoietic factor, did not synergise with IL-5 when both cytokines were given together, but did prime the pigs for a stronger response to IL-5. These results demonstrate that IL-5 can readily be delivered to commercial pigs to elicit a significant biological effect.
机译：细胞因子充当天然免疫治疗剂以增强动物的健康和抗病性的能力是集约化畜牧业特别感兴趣的。抗生素已长期用于这种目的，但是，人们越来越担心这种做法会增强一系列细菌性病原体对抗生素的耐药性。在几个物种中，已知白介素5（IL-5）可增强B细胞活性并增加血液和组织中嗜酸性粒细胞的数量。在该报告中，IL-5以重组蛋白或通过DNA递送载体的形式被递送给猪，并被证明可在持续时间内升高血液中的嗜酸性粒细胞。当两种细胞因子同时给予时，有效的造血因子白介素3不能与IL-5协同作用，但是可以使猪对IL-5产生更强的反应。这些结果证明IL-5可以容易地递送到商业猪以引发显着的生物学作用。

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