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首页> 外文期刊>Cytokine >Chronic viral hepatitis and iron affect the plasma levels of LIGHT-a new member of the TNF superfamily in uraemic haemodialyzed patients.
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Chronic viral hepatitis and iron affect the plasma levels of LIGHT-a new member of the TNF superfamily in uraemic haemodialyzed patients.

机译：慢性病毒性肝炎和铁会影响血浆水平LIGHT-尿毒症血液透析患者的TNF超家族的新成员。

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摘要

LIGHT (lymphotoxin-like inducible protein that competes with glycoprotein D for binding herpesvirus entry mediator on T cells) is a recently identified of the tumor necrosis factor alpha (TNF-alpha) ligand superfamily. We wanted to establish whether the presence of chronic viral hepatitis could be implicated in enhanced inflammation as well as the elevation of plasma LIGHT levels in haemodialyzed (HD) patients. The plasma levels of LIGHT, high sensitivity C-reactive protein (hs CRP) and TNF-alpha were measured in HD patients with hepatitis in comparison to subjects without hepatitis and to healthy volunteers. The values of hs CRP and TNF-alpha were significantly elevated in HD patients when compared to the controls. TNF-alpha levels were significantly higher in the hepatitis-positive relative to the hepatitis-negative group (p <0.01). LIGHT levels were significantly decreased in hepatitis-negative patients as compared to controls (p <0.001) and hepatitis-positive group (p < 0.01). Both LIGHT and TNF-alpha were directly associated with the presence of hepatitis. Multiple stepwise regression analysis identified increased iron levels as the only independent variable significantly associated with increased LIGHT (beta=0.475, p=0.003). These results suggest the presence of chronic viral hepatitis and iron levels are novel determinants of the increased LIGHT in the plasma of HD patients.
机译：LIGHT（与糖蛋白D竞争结合T细胞上的疱疹病毒进入介体的淋巴毒素样诱导型蛋白）是最近发现的肿瘤坏死因子α（TNF-alpha）配体超家族。我们想确定是否慢性病毒性肝炎的存在可能与血液透析（HD）患者的炎症增强以及血浆LIGHT水平升高有关。与没有肝炎的受试者和健康志愿者相比，在患有肝炎的HD患者中测量了LIGHT，高敏C反应蛋白（hs CRP）和TNF-α的血浆水平。与对照组相比，HD患者的hs CRP和TNF-α值显着升高。与肝炎阴性组相比，肝炎阳性组中的TNF-α水平显着更高（p <0.01）。与对照组（p <0.001）和肝炎阳性组（p <0.01）相比，肝炎阴性患者的LIGHT水平显着降低。 LIGHT和TNF-α均与肝炎的存在直接相关。多元逐步回归分析确定，铁水平升高是与LIGHT升高显着相关的唯一独立变量（β= 0.475，p = 0.003）。这些结果表明，慢性病毒性肝炎的存在和铁水平是HD患者血浆中LIGHT升高的新决定因素。

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