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首页> 外文期刊>Cytokine >The effect of compound nutrients on stress-induced changes in serum IL-2, IL-6 and TNF-alpha levels in rats.
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The effect of compound nutrients on stress-induced changes in serum IL-2, IL-6 and TNF-alpha levels in rats.

机译:复合营养素对应激诱导的大鼠血清IL-2,IL-6和TNF-α水平变化的影响。

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摘要

The effect of compound nutrients on serum concentrations of the cytokines, such as interleukin (IL)-2, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in immobilization and cold water-immersion stressed rat were investigated. Oral (gavage) administration of compound nutrients was found to attenuate the acute and chronic immobilization and cold water-immersion stress-induced increase in serum IL-6 level and decrease in IL-2 level. Compound nutrients exerted different effects on TNF-alpha level in two different models studied, with reduced serum TNF-alpha level in acute stress, while no significant effect in chronic stress. These results suggested that compound nutrients might be proposed as a possible candidate in the research or therapeutic modulation of stress-related disorders.
机译:研究了复合营养素对固定化和冷水浸泡应激大鼠血清白细胞介素(IL)-2,肿瘤坏死因子-α(TNF-α)和白细胞介素(IL)-6等细胞因子浓度的影响。口服(管饲)复合营养素可减轻急性和慢性固定作用,以及冷水浸泡应激诱导的血清IL-6水平升高和IL-2水平降低。在两个不同的研究模型中,复合营养素对TNF-α水平有不同的影响,在急性应激中血清TNF-α水平降低,而在慢性应激中无显着影响。这些结果表明,复合营养素可能被提议作为应激相关疾病的研究或治疗性调节的可能候选者。

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