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ADIPOQ gene polymorphisms and cancer risk: A meta-analysis

机译：ADIPOQ基因多态性与癌症风险的荟萃分析

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The results of studies investigating the association between ADIPOQ gene polymorphisms and risk of cancer have been inconsistent and often contradictory. The present meta-analysis was conducted in order to overcome the limitations of any individual study and to provide a more precise overall effect estimate. Relevant studies were identified by searching PubMed and Embase for articles published through May 2012. The strength of the relationship between the ADIPOQ gene and risk of cancer was assessed using odds ratios (ORs). Either a fixed-effects or a random-effects model was used to calculate the overall risk estimates. Fifteen studies were included and five SNPs were considered. A significant association was found between SNP rs2241766 and risk of cancer in the recessive genetic model (OR: 0.768, 95% CI: [0.626,. 0.942], P= 0.011); a significant relationship was also found between SNP rs1501299 and risk of cancer in both an allele contrast (OR: 0.141, 95%CI: [0.113,. 0.176], P< 0.001) and the dominant genetic model (OR: 0.904, 95%CI: [0.830,. 0.985], P= 0.021); no association was found with the rs266729, rs822395, or rs822396 SNPs. Adjusted ORs were also considered, but no statistically significant association was found in homozygote contrasts for any of the five SNPs after adjustment. Our results suggest that two polymorphisms, SNP rs2241766 and SNP rs1501299, of the ADIPOQ gene may be associated with reduced risk of cancer. However, the overall strength of association is mild to moderate, and additional well-designed studies are needed to confirm the present conclusion. ? 2012 Elsevier Ltd.
机译：研究ADIPOQ基因多态性与癌症风险之间关系的研究结果一直是矛盾的，而且常常是矛盾的。进行本荟萃分析是为了克服任何单个研究的局限性，并提供更精确的总体效果评估。通过搜索PubMed和Embase查找截至2012年5月的文章，确定了相关研究。使用比值比（OR）评估ADIPOQ基因与癌症风险之间关系的强度。使用固定效应模型或随机效应模型来计算总体风险估计。纳入15项研究，并考虑了5个SNP。在隐性遗传模型中，SNP rs2241766与癌症风险之间存在显着相关性（OR：0.768，95％CI：[0.626，0.942]，P = 0.011）;在等位基因对比（OR：0.141，95％CI：[0.113，0.176]，P <0.001）和显性遗传模型（OR：0.904，95％）之间，SNP rs1501299与癌症风险之间也发现了显着关系。 CI：[0.830，.0.985]，P = 0.021）;未发现与rs266729，rs822395或rs822396 SNP相关联。还考虑了调整后的OR，但调整后五个SNP的任何一个在纯合子对比中均未发现统计学上的显着关联。我们的结果表明，ADIPOQ基因的两个多态性SNP rs2241766和SNP rs1501299可能与降低癌症风险有关。但是，整体的关联强度是轻度到中度，因此需要进行其他精心设计的研究来确认当前结论。 ？ 2012爱思唯尔有限公司

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