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Single nucleotide polymorphism in the FLT4 gene is associated with atopic dermatitis in Koreans

机译：FLT4基因的单核苷酸多态性与韩国人的特应性皮炎有关

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Background: The histology of atopic dermatitis includes dilated, tortuous vessels within the papillary dermis and perivascular edema. Method: This study included 1120 case-control samples (646 AD patients and 474 normal controls), for which we genotyped 34 SNPs from four VEGF family genes and the FLT4 gene. For the rs11607007 SNP in the VEGFB gene and three SNPs (rs10085109, rs3736062, and rs11949194) in the FLT4 gene, which had significant p-values in the initial stage, were further investigated using 1132 independent samples (440 AD patients and 692 normal controls). Result: Of the four SNPs, rs10085109 in the FLT4 gene was only significantly associated with the AD phenotype in both initial and replication samples. Although no SNPs in the VEGFA gene were significantly associated with AD, the rs2010963 SNP had a marginally significant effect on log-eosinophil counts. Conclusion: The rs10085109 SNP in the FLT4 gene were associated with susceptibility to AD.
机译：背景：特应性皮炎的组织学包括乳头状真皮内扩张的曲折血管和血管周围水肿。方法：本研究包括1120例病例对照样本（646例AD患者和474例正常对照），我们从四个VEGF家族基因和FLT4基因中对34个SNP进行了基因分型。对于VEGFB基因中的rs11607007 SNP和FLT4基因中的三个SNP（rs10085109，rs3736062和rs11949194），它们在初始阶段具有明显的p值，使用1132个独立样本（440名AD患者和692名正常对照）进行了进一步研究）。结果：在这四个SNP中，FLT4基因中的rs10085109仅与初始和复制样品中的AD表型显着相关。尽管VEGFA基因中没有SNP与AD显着相关，但是rs2010963 SNP对对数嗜酸粒细胞计数的影响微乎其微。结论：FLT4基因中的rs10085109 SNP与AD易感性有关。

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